Chemicals

Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1

1 day ago   |   ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 15 April 2021; doi:10.1038/s41589-021-00783-w A substrate-biased activity-based probe technology was developed to enable relatively...
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Senior Scientist, Chemical Process R&D 2021-024 - Mirati Therapeutics Inc - San Diego, CA

1 day ago   |   San Diego Biotechnology   |   7 articles

The Senior Scientist, Chemical Process R&D will be responsible for the design, development and implementation of robust synthetic processes to support Mirati's... From Mirati...
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Advanced Light Source Upgrade Project Achieves Major Milestone

1 day ago   |   News Center

VIDEO: The new swap-out injection system will be implemented as part of the $590 million Advanced Light Source Upgrade project. This unique feature, developed by Berkeley Lab...
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Designing Multi-epitope Diagnosis of Gal d 5 and Gal d 6 Based on Immunoinformatics Approaches Against Egg Yolk Allergy

1 day ago   |   Springer   |   2 articles

Abstract Recent serological tests have shown that children who are allergic to egg white are also susceptible to egg yolk allergen components. Based on the clinical status and...
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Relationship between severity of trunk decay of Pinus koraiensis and soil properties around roots

2 days ago   |   Springer

Abstract The decay rate of standing Korean pine in natural forests can be as high as 50% and is likely influenced by the soil properties and nutrient and water status of the...
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Acyl Donor Stringency and Dehydroaminoacyl Intermediates in β-Lactam Formation by a Non-ribosomal Peptide Synthetase

3 days ago   |   ACS Division of Biological Chemistry

ACS Chemical Biology DOI: 10.1021/acschembio.1c00117
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The HaloTag as a general scaffold for far-red tunable chemigenetic indicators

4 days ago   |   ACS Division of Biological Chemistry   |   2 articles

Nature Chemical Biology, Published online: 01 April 2021; doi:10.1038/s41589-021-00775-w Combining the self-labeling HaloTag protein with synthetic environmentally sensitive...
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Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

4 days ago   |   ACS Division of Biological Chemistry   |   2 articles

Nature Chemical Biology, Published online: 12 April 2021; doi:10.1038/s41589-021-00776-9 A CRISPR-Cas9 screen combined with heparan sulfate -binding reagents identifies genes...
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New aspects of microbial vitamin K2 production by expanding the product spectrum

4 days ago   |   Microbial Cell Factories

Vitamin K2 is an essential lipid-soluble vitamin with critical roles in blood coagulation and bone metabolism. Chemically, the term vitamin K2 encompasses a group of small...
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DeepDSC: A Deep Learning Method to Predict Drug Sensitivity of Cancer Cell Lines

5 days ago   |   IEEE/ACM   |   2 articles

High-throughput screening technologies have provided a large amount of drug sensitivity data for a panel of cancer cell lines and hundreds of compounds. Computational...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Power of light and oxygen clears Alzheimer's disease protein in live mice

A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer's disease... Read more ...

Inferring Metal Binding Sites in Flexible Regions of Proteins

ABSTRACT Metal ions are central to the molecular function of many proteins. Thus their knowledge in experimentally determined structure is important; however, such structures... Read more ...

Molecular basis for higher affinity of SARS‐CoV‐2 spike RBD for human ACE2...

Abstract Severe acute respiratory syndrome coronavirus‐2 has caused substantially more infections, deaths, and economic disruptions than the 2002‐2003 SARS‐CoV. The key to... Read more ...

The vaccine rollout is in full swing. What does that mean for COVID testing?

Public health experts say testing remains an important tool in tracking and controlling the spread of the pandemic Read more ...

Glycol chitosan-based tacrolimus-loaded nanomicelle therapy ameliorates...

Recently, we developed hydrophobically modified glycol chitosan nanomicelles loaded with tacrolimus for the targeted renal delivery of TAC. Herein, we determined whether the... Read more ...

Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer...

Nowadays, a potent challenge in cancer treatment is considered the lack of efficacious strategy, which has not been able to significantly reduce mortality. Chemoimmunotherapy... Read more ...

Alginate-chitosan core-shell microcapsule cultures of hepatic cells in a...

A small scale stirred bioreactor was designed and the effect of different agitation rates was investigated on HepG2 cells cultured in alginate-chitosan core-shell microcapsule... Read more ...

Aliphatic extractive effects on acetic acid catalysis of typical...

Xylo-oligosaccharide is the spotlight of functional sugar that improves the economic benefits of lignocellulose biorefinery. Acetic acid acidolysis technology provides a... Read more ...

Multi-omics analysis provides insights into lignocellulosic biomass...

Wood-decay basidiomycetes are effective for the degradation of highly lignified and recalcitrant plant substrates. The degradation of lignocellulosic materials by brown-rot... Read more ...

Lyophilized alginate-based microspheres containing Lactobacillus fermentum...

Lactobacillus fermentum D12 is an exopolysaccharide producing strain whose genome contains a putative eps operon. Whole-genome analysis of D12 was performed to disclose the... Read more ...