Drugs

Ontology-based identification and prioritization of candidate drugs for epilepsy from literature

7 hours ago   |   Journal of Biomedical Semantics

Drug repurposing can improve the return of investment as it finds new uses for existing drugs. Literature-based analyses exploit factual knowledge on drugs and diseases, e.g...
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Capricor gets up to $735M for Duchenne drug's US rights; PCI Biotech ends bile duct cancer clinical trial

12 hours ago   |   San Diego Biotechnology   |   2 articles

Capricor Therapeutics is still chugging along. The San Diego biotech signed a new collaboration with Japanese pharma company Nippon Shinyaku, whose US subsidiary is NS Pharma...
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Stabilizing protein drugs with a new reversible 'mixing-type' material

13 hours ago   |   Phys

Protein drugs are widely used as pharmaceutical agents to treat a range of disorders. However, most of these drugs are not very stable and are only retained in the blood...
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Epigenetic landscape of drug responses revealed through large-scale ChIP-seq data analyses

13 hours ago   |   BMC Bioinformatics

Elucidating the modes of action of drugs and drug candidate compounds is critical for guiding translation from drug discovery to clinical application. Despite the development...
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Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery

15 hours ago   |   Journal of Nanobiotechnology

A widely established prodrug strategy can effectively optimize the unappealing properties of therapeutic agents in cancer treatment. Among them, lipidic prodrugs extremely...
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Sierra's bet on Gilead castoff pays off, teeing up FDA filing for rival to Incyte-Novartis cancer drug

15 hours ago   |   Fierce Biotech

Sierra's bet on Gilead castoff pays off, teeing up FDA filing for rival to Incyte-Novartis cancer drug ntaylor Tue, 01/25/2022 - 08:10
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Senhwa's Pidnarulex Receives US FDA Fast Track Designation for the Treatment of Solid Tumors with BRCA1/2, PALB2 and other HR Gene Mutations

16 hours ago   |   San Diego Biotechnology

TAIPEI and SAN DIEGO: TAIPEI and SAN DIEGO, Jan. 25, 2022 /PRNewswire/ - Senhwa Biosciences, Inc. , a drug development company focusing on first-in-class therapeutics for...
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Quality Control Associate, Flow Cytometry - UC San Diego - San Diego, CA

1 day ago   |   San Diego Biotechnology   |   14 articles

As a federally-funded institution, UC San Diego Health maintains a marijuana and drug free campus. For the safety and well-being of the entire university...From UC San Diego...
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Optical HW Engineering Technician - NanoCellect Biomedical, Inc. - San Diego, CA

1 day ago   |   San Diego Biotechnology   |   11 articles

Our microfluidic flow cytometry platforms enable biomedical scientists to analyze and sort cells required for drug discovery, single cell-omics, cloning, and...From NanoCellect...
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Senior Scientist, Systems Biology - Ionis Pharmaceuticals, Inc. - Carlsbad, CA

1 day ago   |   San Diego Biotechnology   |   11 articles

Analyze single cell and bulk 'omics data from preclinical models to inform target discovery, novel combinations, disease subtypes and drug mode of action.From Ionis...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

An unexpected attraction of nucleic acids and fat

All cells on Earth are enveloped in a fatty layer of lipids. Lipid membranes protect the content of the cells, including genetic information such as RNA and DNA. A new study... Read more ...

Designed SARS‐CoV‐2 receptor binding domain variants form stable monomers

Abstract The receptor binding domain of the SARS-CoV-2 spike -protein is a prime target of virus-neutralizing antibodies present in convalescent sera of COVID-19 patients and... Read more ...

Engineering Acetobacterium woodii for the production of isopropanol and...

Abstract The capability of four genetically modified A. woodii strains for improved production of acetone from CO 2 and hydrogen was tested. The acetone biosynthesis pathway... Read more ...

L‐Lactate oxidase‐mediated removal of L‐lactic acid derived from...

Abstract Background : There has been an increasing demand for optically pure D-lactic and L-lactic acid for the production of stereocomplex-type polylactic acid. The D-lactic... Read more ...

Structure‐based discovery of small molecules improving stability of human...

Abstract The production of biopharmaceuticals in engineered plant-based systems is a promising technology that has proven its suitability for the production of various... Read more ...

Leaf Angle: A Target of Genetic Improvement in Cereal Crops Tailored for...

Summary High-density planting is an effective measure for increasing crop yield per unit land area. Leaf angle is a key trait of plant architecture and a target for genetic... Read more ...

Ontology-based identification and prioritization of candidate drugs for...

Drug repurposing can improve the return of investment as it finds new uses for existing drugs. Literature-based analyses exploit factual knowledge on drugs and diseases, e.g... Read more ...

Proliferation and differentiation of primary bovine myoblasts using...

Abstract Recently, cultured meat obtained from livestock-derived cells is being considered as a sustainable food source that reduces the use of natural resources. This study... Read more ...

Novel modified culture medium for enhancing redifferentiation of...

Abstract The dedifferentiation of articular chondrocytes during in vitro expansion deteriorates the hyaline cartilage regeneration. Many approaches have been developed to... Read more ...

UFGI Publication Round-up: Week of 1/24/22

Mitogen-Activated Protein Kinase 4-Regulated Metabolic Networks. Lin C, Lott AA, Zhu W, Dufresne CP, Chen S. Int J Mol Sci. 2022 Jan 14;23(2):880. doi... Read more ...