Bioinformatic

Immunoinformatics prediction of potential immunodominant epitopes from human coronaviruses and association with autoimmunity

8 days ago   |   By Springer

Abstract
Cross-reactivity between different human coronaviruses might contribute to COVID-19 outcomes. Here, we aimed to predict conserved peptides among different HCoVs that could elicit cross-reacting B cell and T cell responses. Three hundred fifty-one full-genome sequences of HCoVs, including SARS-CoV-2 (51), SARS-CoV-1 (50), MERS-CoV (50), and common cold species OC43 (50), NL63 (50), 229E (50), and HKU1 (50) were downloaded aligned using Geneious Prime 20.20. Identification of epitopes in the conserved regions of HCoVs was carried out using the Immune Epitope Database to predict B...
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Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology

8 days ago   |   By Springer

Abstract
Background
Severe Acute Respiratory Syndrome Coronavirus 2 causes coronavirus disease 2019 through direct lysis of infected lung epithelial cells, which releases damage-associated molecular patterns and induces a pro-inflammatory cytokine milieu causing systemic inflammation. Anti-viral and anti-inflammatory agents have shown limited therapeutic efficacy. Soluble CD24 blunts the broad inflammatory response induced by damage-associated molecular patterns via binding to extracellular high mobility group box 1 and heat shock proteins, as well as regulating the downstream Siglec10-Src...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Biological modification of pentosans in wheat B starch wastewater and...

Petrochemical resources are becoming increasingly scarce, and petroleum-based plastic materials adversely impact the environment. Thus, replacement of petroleum-based materials... Read more ...

Research Associate - Molecular Cellular Biologist - Activx - La Jolla, CA

The successful candidate will work with senior scientists to design and execute experiments to validate drug targets and to characterize compounds that modulate... $48,000... Read more ...

N-Lorem Foundation Partners with Alnylam to Expand Technology Access to RNAi...

SAN DIEGO-- ASO-n-Lorem and Alnylam Partner to Expand Technology Access to RNAi Read more ...

The amyloid concentric β‐barrel hypothesis: Models of amyloid beta 42...

Abstract Amyloid beta peptides are a major contributor to Alzheimers disease. They occur in differing lengths, each of which forms a multitude of assembly types. The most toxic... Read more ...

Crystal Structure of a Human MUC16 SEA Domain Reveals Insight Into the...

Abstract MUC16 is a membrane bound glycoprotein involved in the progression and metastasis of pancreatic and ovarian cancer. The protein is shed into the serum and the... Read more ...

Senior Mechanical Design Engineer - NanoCellect Biomedical, Inc. - San Diego, CA

Our microfluidic flow cytometry platforms enable biomedical scientists to analyze and sort cells required for drug discovery, single cell-omics, cloning, and...From NanoCellect... Read more ...

Kurin, Inc. Announces Agreement with AllSpire Health GPO to Impact...

SAN DIEGO--Kurin, Inc. announced the signing of a sole-source, three-year agreement with AllSpire Health GPO for Kurin blood culture collection sets. Read more ...

PhenoVista Biosciences Raises Growth Capital From BroadOak Capital Partners

SAN DIEGO--PhenoVista Biosciences announces investment from BroadOak Capital Partners. Read more ...

Advances in 3D printing of composite scaffolds for the repairment of bone...

Abstract The conventional methods of using autografts and allografts for repairing defects in bone, the osteochondral bone and the cartilage tissue have many disadvantages... Read more ...

Ionis' partner to evaluate tominersen for Huntington's disease in new Phase...

CARLSBAD, Calif.: CARLSBAD, Calif., Jan. 18, 2022 /PRNewswire/ - Ionis Pharmaceuticals, Inc. announced that its partner, Roche, is designing a new Phase 2 trial to evaluate... Read more ...