Bioinformatics

Truncation of the N-terminus of cardiac troponin I initiates adaptive remodeling of the myocardial proteosome via phosphorylation of mechano-sensitive signaling pathways

15 days ago   |   By Springer

Abstract
The cardiac isoform of troponin I has a unique N-terminal extension , which contributes to the modulation of cardiac contraction and relaxation. Hearts of various species including humans produce a truncated variant of cardiac troponin I deleting the first ~ 30 amino acids as an adaption in pathophysiological conditions. In this study, we investigated the impact of cTnI-ND chronic expression in transgenic mouse hearts compared to wildtype controls. We aimed to determine the global phosphorylation effects of cTnI-ND on the cardiac proteome, thereby determining the signaling...
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