Biologic
NAD+ supplementation improves mAb productivity in CHO cells via a glucose metabolic shift
1 month ago | By Wiley
Abstract
Aerobic glycolysis and its by-product lactate accumulation are usually associated with adverse culture phenotypes such as poor cell viability and productivity. Due to the lack of knowledge on underlying mechanisms and accompanying biological processes, the regulation of aerobic glycolysis has been an ongoing challenge in culture process development for therapeutic protein productivity. NAD + , a coenzyme and co-substrate in energy metabolism, promotes the conversion of inefficient glycolysis into an efficient oxidative phosphorylation pathway. However, the effect of NAD + on CHO...
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