Cancer

HCG11 up-regulation induced by ELK4 suppressed proliferation in vestibular schwannoma by targeting miR-620/ELK4

22 days ago   |   By Springer

Abstract
Background
Vestibular schwannoma is a kind of benign tumor deriving from the acoustic nerve sheath. Substantial long non-coding RNAs were illustrated to have crucial roles in multiple cancers. However, few lncRNAs were elucidated in VS.
Methods
HCG11, miR-620 and ELK4 expression were tested by RT-qPCR. Gain-of-function experiments were conducted to confirm the effect of HCG11 on VS.
Results
HCG11 possessed a low expression in VS cell lines. Overexpression of HCG11 repressed cell proliferation but accelerated apoptosis of VS cells. Moreover, we identified ELK4 stimulated the...
Read more ...

 


Search by Tags

   Cancer  


World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Bond LSC Researchers Named Most Highly Cited for 2020

Bond LSC Researchers Named Most Highly Cited for 2020

Bond Life Sciences Center principal investigators Bing Yang and Ron Mittler are pictured above. | photos by Erica Overfelt, Bond LSC. By Lauren Hines | Bond LSC Building onto... Read more ...

A New Way to Measure Record-Setting Electron Beams

A New Way to Measure Record-Setting Electron Beams

Sam Barber, left, a research scientist at Berkeley Lab's BELLA Center, and Jeroen van Tilborg, a staff scientist at the BELLA Center, hold the active plasma lens, right, and... Read more ...

Researchers Find Cerebrospinal Fluid Boosts Cancer Cell Aggression

Researchers Find Cerebrospinal Fluid Boosts Cancer Cell Aggression

In cell studies, Mayo researchers and collaborators have uncovered why tumor cells from glioblastoma are more aggressive in one part of the brain than in others. In an article... Read more ...

Historical evolution of spheroids and organoids, and possibilities of use in...

Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicine

Abstract Background An impressive percentage of biomedical advances were achieved through animal research and cell culture investigations. For drug testing and disease... Read more ...

Salk scientists awarded $1.2 million by Larry L. Hillblom Foundation to...

LA JOLLA-A collaborative team of Salk scientists led by Professor John Reynolds will receive $1.2 million over four years as part of a Network Grant from the Larry L. Hillblom... Read more ...

Efficient Multiple Biomedical Events Extraction Via Reinforcement Learning

AbstractMotivationMultiple events extraction from biomedical literature is a challenging task for biomedical community. Usually, biomedical event extraction is modeled as two... Read more ...

Calibrating variant-scoring methods for clinical decision making

AbstractIdentifying pathogenic variants and annotating them is a major challenge in human genetics, especially for the non-coding ones. Several tools have been developed and... Read more ...

Structure and binding ability of self‐assembled α‐lactalbumin protein...

Abstract Partial hydrolysis of whey‐based α‐lactalbumin with Bacillus licheniformis protease induces the formation of nanotubular structures in the presence of calcium ions by... Read more ...

Anti‐epithelial cell adhesion molecule RNA aptamer‐conjugated liposomal...

Abstract To overcome the lack of selectivity and nonspecific biodistribution of drugs in the body, targeted delivery of chemotherapeutic agents with aptamers is a very... Read more ...

Devices and techniques used to obtain and analyse 3‐Dimensional cell cultures

Abstract Cell cultures are indispensable for both basic and applied research. Advancements in cell culture and analysis increase their utility for basic research and... Read more ...