Cellular

Upregulated LINC01088 facilitates malignant phenotypes and immune escape of colorectal cancer by regulating microRNAs/G3BP1/PD-L1 axis

25 days ago   |   By Springer

Abstract
Purpose
Long intergenic non-coding RNA LINC01088 is a newly discovered long non-coding RNA. Its biological function in colorectal cancer remains unknown.
Methods
Here, 36 paired CRC and para-cancerous tissues were collected. In vitro, fluorescence in situ hybridization assay, qPCR, western blotting analysis and cellular functional experiments, RNA immunoprecipitation assay and dual-luciferase reporter system analysis were performed. In vivo, xenograft tumor mouse models were generated. Besides, patient-derived intestinal organoid was generated ex vivo.
Results
We found that...
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MiR-144 inhibits the IGF1R-ERK1/2 signaling pathway via NUDCD1 to suppress the proliferation and metastasis of colorectal cancer cells: a study based on bioinformatics and in vitro and in vivo verification

25 days ago   |   By Springer

Abstract
Purpose
Colorectal cancer is a severe health condition characterized by high mortalities. NudC domain containing 1 is abnormally upregulated in multiple tumors and is recognized as a cancer antigen. In CRC, NUDCD1 upregulation accelerates tumor progression by activating the IGF1R-ERK1/2 signaling pathway. Its specific regulatory mechanisms, however, remain unclear.
Methods
In the present study, we predicted the regulators of NUDCD1 and analyzed the expression profile of NUDCD1 in CRC tissues using the gene chip dataset. We also determined the regulation between miR-144, NUDCD1 and...
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World Biotechnology Congress 2019

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