RNA

ScMRA: A robust deep learning method to annotate scRNA-seq data with multiple reference datasets

7 days ago   |   By Oxford Journals

AbstractMotivationSingle-cell RNA-seq has been widely used to resolve cellular heterogeneity. After collecting scRNA-seq data, the natural next step is to integrate the accumulated data to achieve a common ontology of cell types and states. Thus, an effective and efficient cell-type identification method is urgently needed. Meanwhile, high quality reference data remain a necessity for precise annotation. However, such tailored reference data are always lacking in practice. To address this, we aggregated multiple datasets into a meta-dataset on which annotation is conducted. Existing...
Read more ...

 

Clustering Spatial Transcriptomics Data

7 days ago   |   By Oxford Journals

AbstractMotivationRecent advancements in fluorescence in situ hybridization techniques enable them to concurrently obtain information on the location and gene expression of single cells. A key question in the initial analysis of such spatial transcriptomics data is the assignment of cell types. To date, most studies used methods that only rely on the expression levels of the genes in each cell for such assignments. To fully utilize the data and to improve the ability to identify novel sub-types we developed a new method, FICT, which combines both expression and neighborhood information...
Read more ...

 

SMILE: Mutual Information Learning for Integration of Single-cell Omics Data

7 days ago   |   By Oxford Journals

AbstractMotivationDeep learning approaches have empowered single-cell omics data analysis in many ways and generated new insights from complex cellular systems. As there is an increasing need for single cell omics data to be integrated across sources, types, and features of data, the challenges of integrating single-cell omics data are rising. Here, we present an unsupervised deep learning algorithm that learns discriminative representations for single-cell data via maximizing mutual information, SMILE ( S ingle-cell M utual I nformation Le arning).ResultsUsing a unique cell-pairing...
Read more ...

 


Search by Tags

   RNA      Nature      Cellular      Genes      Gene      DNA      Tissue  


World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Long-Term Stable Reduction of Low-Density Lipoprotein in Nonhuman Primates...

Wang, L. et al. Molecular Therapy. 6, 2019-2029 (2021). Read more ...

Mitochondrial Targeted Meganuclease as a Platform to Eliminate Mutant mtDNA...

Zekonyte, U. et al. Nat Commun. 12, 3210 (2021). Read more ...

Scientists map brain circuit that drives activity in fertile females

Scientists have known for a century that female animals become more active just as they are about to ovulate, a behavior that evolved to enhance their chances of mating when... Read more ...

A new method inspired by kid's pop-up books for making 3D artificial tissue

University at Buffalo researchers have developed a new process for creating three-dimensional artificial tissue, an advancement that could improve experimental drug testing... Read more ...

Inhalable anti-COVID-19 antibody from TFF and Augmenta tamps down viral load...

Inhalable anti-COVID-19 antibody from TFF and Augmenta tamps down viral load in hamsters arlene.weintraub Fri, 10/15/2021 - 08:26 Read more ...

AstraZeneca delivers rare win for treme in liver cancer, bouncing back from...

AstraZeneca delivers rare win for treme in liver cancer, bouncing back from flops to beat Bayer's Nexavar ntaylor Fri, 10/15/2021 - 07:58 Read more ...

Pharma veterans regroup with $50M and a plan to discover new multi-specifics

While a horde of drugmakers develops bispecific antibodies to more directly target tumor cells - there were about 100 programs in or nearing clinical trials back in May - a new... Read more ...

Chinese biopharma powerhouse continues charge into siRNA with Silence R&D pact

Chinese biopharma powerhouse continues charge into siRNA with Silence R&D pact ntaylor Fri, 10/15/2021 - 04:33 Read more ...

Quantitative prediction model for affinity of drug-target interactions based...

The study of drug-target interactions affinity plays an important role in safety assessment and pharmacology. Currently, quantitative structure-activity relationship and... Read more ...

Modularity‐based Parallel Protein Design Algorithm with an Implementation...

Abstract Given a target protein structure, the prime objective of protein design is to find amino acid sequences that will fold/acquire to the given three-dimensional... Read more ...