Chemical

Chemically informed analyses of metabolomics mass spectrometry data with Qemistree

5 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00677-3 Qemistree uses fragmentation spectra to predict molecular fingerprints and represent their relationships as a tree, enabling comparison of metabolomics data across different experimental conditions and exploration of chemical diversity in mixtures.
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Ion channels as lipid sensors: from structures to mechanisms

5 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00693-3 Ion channel structures reveal mechanisms of lipid action, including how channel gating is altered by direct binding of signaling lipids and those within the membrane itself, as well as mechanical and architectural effects of membrane lipids.
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Cell type-selective secretome profiling in vivo

5 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00698-y A proximity labeling strategy enables enrichment of cell type-selective secretomes in mice by direct biochemical purification of biotinylated polypeptides from blood plasma.
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Defining new chemical space for drug penetration into Gram-negative bacteria

5 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00674-6 The difficulty of antibiotic discovery posed by the double-membrane cell envelope of Gram-negative bacteria and active drug efflux requires better understanding of bacterial permeability and compound accumulation, and more diverse chemical libraries.
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

5 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00686-2 The authors report PROTAC ternary complex structures involving the E3 ligase cIAP1 and target protein BTK, showing that cooperativity is not always correlated with degradation efficiency.
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The conformational cycle of a prototypical voltage-gated sodium channel

5 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-0644-4 The conformational cycle of a bacterial voltage-gated sodium channel as it transitions from resting to activated open to inactivated closed states can be constructed from various crystal structure snapshots.
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Delimiting lipids

5 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00701-6 This themed issue features a collection of articles that explore long-standing questions in the study of lipids and membranes.
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Making use of surplus sugar

5 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00687-1 Insects have many ways of disabling plant chemical defenses during feeding. Plant phloem feeders use surplus ingested sugar to block the activation of glucosinolate toxins, providing a target for precise resistance breeding.
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Wired interview Andrey Zarur

Wired interview Andrey Zarur

“Manufacturing enough Covid-19 vaccine is a logistical nightmare” GreenLight CEO Andrey Zarur tells Wired: “2,000 litre bioreactor might yield 100 times more vaccine than a... Read more ...

Better Apple Pies: HiFi Reads are a Perfect Recipe...

Better Apple Pies: HiFi Reads are a Perfect Recipe for High-Quality Apple Genome and Pangenome Assemblies 

Zhangjun Fei inspects a Mutsu apple at Indian Creek Farm in Ithaca, NY. Image credit: Boyce Thompson Institute Scientists at the Boyce Thompson Institute, Cornell University... Read more ...

New insights into how the CRISPR immune system evolved

Although CRISPR-Cas has found many uses in biotechnology and medicine, it originates in nature, where it functions as a microbial immune system. Scientists shed new light on... Read more ...

New plant-based gel to fast-track 'mini-organs' growth, improve cancer treatment

Researchers have created the world's first bioactive plant-based nanocellulose hydrogel to support organoid growth for biomedical applications. This includes cancer development... Read more ...

Metabolic engineering of Saccharomyces cerevisiae for high-level production...

The natural phenolic glycoside gastrodin is the major bioactive ingredient in the well-known Chinese herb Tianma and is widely used as a neuroprotective medicine in the clinic... Read more ...

Dual and mutual interaction between microbiota and viral infections: a...

All of humans and other mammalian species are colonized by some types of microorganisms such as bacteria, archaea, unicellular eukaryotes like fungi and protozoa, multicellular... Read more ...

Efficient protection of microorganisms for delivery to the intestinal tract...

Gut microbiota in humans and animals play an important role in health, aiding in digestion, regulation of the immune system and protection against pathogens. Changes or... Read more ...

Scientists develop new gene therapy for eye disease

Scientists have developed a new gene therapy approach that offers promise for one day treating an eye disease that leads to a progressive loss of vision and affects thousands... Read more ...

The comparison of miRNAs that respond to anti-breast cancer drugs and usnic...

Abstract This study was designed to compare usnic acid with anti-breast cancer drug molecules routinely used in the treatment of breast cancer. The miRNA information of 17... Read more ...

Spatially Aware Dense-LinkNet Based Regression Improves Fluorescent Cell...

Recent advancements in ophthalmic imaging technology, based on adaptive optics , have enabled fluorescence imaging of retinal pigment epithelial cells directly inside the... Read more ...