Chemical

Launching the missile

7 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00683-5 Launching the missile
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It's a trap!

7 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00680-8 It's a trap!
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Advanced rules of relays

7 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-0632-8 Transfer of ubiquitin onto target proteins requires controlled interplay between E2 conjugating enzymes and E3 ligases. The structure of a trapped E2~Ub/RCR E3 transfer intermediate provides novel insight into the diversity of mechanisms used to fine tune this relay.
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Hijacking protein degradation

7 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00685-3 Targeted protein degradation provides a powerful complement to small-molecule inhibition in modulating protein activity and allows access to otherwise intractable drug targets.
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Clarifying the translational potential of B-I09

7 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00654-w Clarifying the translational potential of B-I09
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Kinase ins and outs

7 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00682-6 Kinase ins and outs
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Reversal of nucleobase methylation by dioxygenases

7 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00675-5 This Review summarizes the chemical and physical properties of methylated nucleobases in DNA and RNA, proposes a chemical classification of methylation types, and discusses recent advance in demethylation reactions mediated by dioxygenases.
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Fine-tuning adhesives

7 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00681-7 Fine-tuning adhesives
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World Biotechnology Congress 2019

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