Drug

Conversion of five proluciferin esters by human cytochrome P450 enzymes

2 days ago   |   By Wiley

Abstract
Background
Probe substrates are an important tool for activity monitoring of human drug metabolizing enzymes such as cytochromes P450 .
Brief methods
In the present study we have tested human CYPs for metabolization of five proluciferin ester substrates which had previously only been known to be hydroxylated by CYP26A1.
Major results
It was found that these substrates were converted by another 21 human CYPs, which belong to the CYP families 1 to 4, 7, and 26. Thus, 66 new pairs of enzyme and substrate were identified. Correlation analysis indicated the presence of three distinct...
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