Virus

Molecular dynamics analysis of a flexible loop at the binding interface of the SARS‐CoV‐2 spike protein receptor‐binding domain

2 days ago   |   By Wiley

Abstract
Since the identification of the SARS-CoV-2 virus as the causative agent of the current COVID-19 pandemic, considerable effort has been spent characterizing the interaction between the Spike protein receptor-binding domain and the human angiotensin converting enzyme 2 receptor. This has provided a detailed picture of the end point structure of the RBD-ACE2 binding event, but what remains to be elucidated is the conformation and dynamics of the RBD prior to its interaction with ACE2. In this work, we utilize molecular dynamics simulations to probe the flexibility and conformational...
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Crystal‐Structures‐Guided Design of Fragment‐Based Drugs for Inhibiting the Main Protease of SARS‐CoV‐2

2 days ago   |   By Wiley

Abstract
Since the beginning of the COVID-19 pandemic, scientists across the globe are racing to find a cure for the highly contagious infectious disease caused by the SARS-CoV-2 virus. Despite many promising ongoing progress, there are currently no FDA approved drug to treat infected patients. Recently, the crowdsourcing of drug discovery for inhibiting the main protease of SARS-CoV-2 have yielded a plenty of drug fragments resolved inside the active site of Mpro via the crystallography method. Following the principle of fragment-based drug design , we are motivated to design a potent...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Long-Term Stable Reduction of Low-Density Lipoprotein in Nonhuman Primates...

Wang, L. et al. Molecular Therapy. 6, 2019-2029 (2021). Read more ...

Mitochondrial Targeted Meganuclease as a Platform to Eliminate Mutant mtDNA...

Zekonyte, U. et al. Nat Commun. 12, 3210 (2021). Read more ...

Scientists map brain circuit that drives activity in fertile females

Scientists have known for a century that female animals become more active just as they are about to ovulate, a behavior that evolved to enhance their chances of mating when... Read more ...

A new method inspired by kid's pop-up books for making 3D artificial tissue

University at Buffalo researchers have developed a new process for creating three-dimensional artificial tissue, an advancement that could improve experimental drug testing... Read more ...

Inhalable anti-COVID-19 antibody from TFF and Augmenta tamps down viral load...

Inhalable anti-COVID-19 antibody from TFF and Augmenta tamps down viral load in hamsters arlene.weintraub Fri, 10/15/2021 - 08:26 Read more ...

AstraZeneca delivers rare win for treme in liver cancer, bouncing back from...

AstraZeneca delivers rare win for treme in liver cancer, bouncing back from flops to beat Bayer's Nexavar ntaylor Fri, 10/15/2021 - 07:58 Read more ...

Pharma veterans regroup with $50M and a plan to discover new multi-specifics

While a horde of drugmakers develops bispecific antibodies to more directly target tumor cells - there were about 100 programs in or nearing clinical trials back in May - a new... Read more ...

Chinese biopharma powerhouse continues charge into siRNA with Silence R&D pact

Chinese biopharma powerhouse continues charge into siRNA with Silence R&D pact ntaylor Fri, 10/15/2021 - 04:33 Read more ...

Quantitative prediction model for affinity of drug-target interactions based...

The study of drug-target interactions affinity plays an important role in safety assessment and pharmacology. Currently, quantitative structure-activity relationship and... Read more ...

Modularity‐based Parallel Protein Design Algorithm with an Implementation...

Abstract Given a target protein structure, the prime objective of protein design is to find amino acid sequences that will fold/acquire to the given three-dimensional... Read more ...