Chemical

Chemically informed analyses of metabolomics mass spectrometry data with Qemistree

2 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00677-3 Qemistree uses fragmentation spectra to predict molecular fingerprints and represent their relationships as a tree, enabling comparison of metabolomics data across different experimental conditions and exploration of chemical diversity in mixtures.
Read more ...

 

Ion channels as lipid sensors: from structures to mechanisms

2 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00693-3 Ion channel structures reveal mechanisms of lipid action, including how channel gating is altered by direct binding of signaling lipids and those within the membrane itself, as well as mechanical and architectural effects of membrane lipids.
Read more ...

 

Cell type-selective secretome profiling in vivo

2 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00698-y A proximity labeling strategy enables enrichment of cell type-selective secretomes in mice by direct biochemical purification of biotinylated polypeptides from blood plasma.
Read more ...

 

Defining new chemical space for drug penetration into Gram-negative bacteria

2 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00674-6 The difficulty of antibiotic discovery posed by the double-membrane cell envelope of Gram-negative bacteria and active drug efflux requires better understanding of bacterial permeability and compound accumulation, and more diverse chemical libraries.
Read more ...

 

Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

2 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00686-2 The authors report PROTAC ternary complex structures involving the E3 ligase cIAP1 and target protein BTK, showing that cooperativity is not always correlated with degradation efficiency.
Read more ...

 

The conformational cycle of a prototypical voltage-gated sodium channel

2 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-0644-4 The conformational cycle of a bacterial voltage-gated sodium channel as it transitions from resting to activated open to inactivated closed states can be constructed from various crystal structure snapshots.
Read more ...

 

Delimiting lipids

2 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00701-6 This themed issue features a collection of articles that explore long-standing questions in the study of lipids and membranes.
Read more ...

 

Making use of surplus sugar

2 days ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00687-1 Insects have many ways of disabling plant chemical defenses during feeding. Plant phloem feeders use surplus ingested sugar to block the activation of glucosinolate toxins, providing a target for precise resistance breeding.
Read more ...

 


Search by Tags

   Chemical      Chemicals      Biological      Nature      Biology      Biologic      Nat Chem Biol      Publications      Biochemical      Drugs      Drug      Antibiotics      Discovery      Protein      Feed      Plants  


World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Scientists Design New Framework for Clean Water

Scientists Design New Framework for Clean Water

Artist's illustration of water molecules. A research team led by Berkeley Lab has designed a new crystalline material that targets and traps copper ions from wastewater with... Read more ...

From FAANG to fork: application of highly annotated genomes to improve...

Read more ...

Bioinformatics Computer Programmer Paternostro Lab - Sanford Burnham Prebys...

Possess strong attention to detail and organizational skills. The Programmer will be using computational methods to assist in interpreting high throughput...From Sanford... Read more ...

Research Tech I - La Jolla Institute for Immunology - San Diego, CA

This position requires a 2 to 5 -year commitment. A full-time position for a research technician is immediately available in the Division of Vaccine Discovery...From La Jolla... Read more ...

Commonly used antibiotic shows promise for combating Zika infections

Researchers used a variety of advanced drug screening techniques to test out more than 10,000 compounds in search of a cure. To their surprise, they found that the widely used... Read more ...

CRISPRi screens reveal sources of metabolic robustness in E. coli

Metabolic robustness, the ability of a metabolic system to buffer changes in its environment, is not always a welcome feature for microbiologists: it interferes with metabolic... Read more ...

Enzymatic photocaging for the study of gene regulation through DNA methylation

The addition and removal of methyl groups on DNA plays an important role in gene regulation. In order to study these mechanisms more precisely, a team has developed a new... Read more ...

Greater glider species triple

Researchers analyzed the genetic make-up of the greater glider - a possum-sized marsupial that can glide up to 100 meters. The team confirmed a long-held theory that the... Read more ...

Members of Congress Finding Agreement on a Tech Antitrust Agenda

House Democrats and Republicans are finding common ground on a set of principles for countering tech monopolies that they believe could drive a bipartisan push in the new... Read more ...

Chemist - GenMark Diagnostics - Carlsbad, CA

Document all work according to GLP and GMP. Chemist in the efforts to manufacture custom oligonucleotides for the assay development teams and production.From GenMark... Read more ...