Gene

A new mechanism behind continuous stem cell activity in plants

9 days ago   |   By Phys

An inter-university research group has succeeded in constructing the gene expression network behind the vascular development process in plants. They achieved this by performing bioinformatics analysis using the 'VISUAL' tissue culture platform, which generates vascular stem cells from leaf cells. In this network, they also discovered a new BES/BZR transcription factor, BEH3, which regulates vascular stem cells. In addition, they illuminated a novel vascular cell maintenance system whereby BEH3 competes with other transcription factors from the same BES/BZR family in order to stabilize...
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Impact of miRNAs expression modulation on the methylation status of breast cancer stem cell-related genes

9 days ago   |   By Springer

Abstract
Purpose
Altered miRNAs play a crucial role in the emergence of the breast cancer stem cell phenotype. The interplay between miRNAs and methylation enzymes has been documented. One of the most aggressive breast cancer cell lines, MDA-MB-231, has expressed much more DNMT3B than DNMT3A. This study aims to evaluate the ability of miR-203 restoration and miR-150 inhibition to regulate DNMT3B and DNMT3A to modify the methylation level of BCSC-associated genes.
Methods
MDA-MB-231 cells were transfected with miR-203 mimic or miR-150 inhibitor or DNMT3B siRNA, and downstream analysis was...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Warehouse Associate - Inovio Pharmaceuticals - San Diego, CA

The temporary Warehouse Associate is responsible for safely performing the assigned warehouse functions, such as monitoring and reconciling inventory levels,...From Indeed... Read more ...

Zeroing in on APOE gene to better understand aging, Alzheimer's disease

Zeroing in on APOE gene to better understand aging, Alzheimer's disease

The apolipoprotein E, or APOE , gene is the strongest genetic risk factor for Alzheimer's disease , as most people who get the disease carry the gene. The gene has far-reaching... Read more ...

Modular biosynthesis of plant hemicellulose and its impact on yeast cells

The carbohydrate polymers that encapsulate plants cells have benefited humans for centuries and have valuable biotechnological uses. In the past 5 years, exciting possibilities... Read more ...

Genetic tools for the development of recombinant lactic acid bacteria

Lactic acid bacteria are a phylogenetically diverse group with the ability to convert soluble carbohydrates into lactic acid. Many LAB have a long history of safe use in... Read more ...

How cells 'read' artificial ingredients tossed into genetic recipe

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Start-stop system of hunting immune cells

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Research Associate - Synthetic Genomics - La Jolla, CA

The successful candidate will support the characterization of metagenomic communities, isolation and characterization of individual strains, and development of...From Synthetic... Read more ...

Author Correction: Highly recurrent CBS epimutations in gastric cancer CpG...

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LIQA: long-read isoform quantification and analysis

Long-read RNA sequencing technologies can sequence full-length transcripts, facilitating the exploration of isoform-specific gene expression over short-read RNA-seq. We present... Read more ...

Hired blade: Anchoring complex in plant cells recruits its own katana sword

Researchers have found that an anchoring complex in plant cells recruits its own version of the katana sword for cutting microtubules. The Msd1-Wdr8 complex is used to... Read more ...