Human Genome

Single-cell CRISPR technology deciphers role of chromatin accessibility in cancer

6 days ago   |   By Phys

In a new resource for the scientific community, published today in Nature Biotechnology, researchers in the lab of Neville Sanjana, Ph.D., at the New York Genome Center and New York University developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. With this technology, they profile changes in genome organization and create a large-scale atlas of how loss of individual chromatin-altering enzymes impacts the human genome. The new method harnesses the programmability of the...
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