Industrial

Engineering the oleaginous yeast Yarrowia lipolytica for β‐farnesene overproduction

1 day ago   |   By Wiley

Abstract
β‐farnesene is a sesquiterpenoid with various industrial applications which is now commercially produced by a Saccharomyces cerevisiae strain obtained by random mutagenesis and genetic engineering. We rationally designed a genetically defined Yarrowia lipolytica through recovery of L‐leucine biosynthetic route, gene dosage optimization of β‐farnesene synthase and disruption of the competition pathway. The resulting β‐farnesene titer was improved from 8 mg/L to 345 mg/L. Finally, the strategy for decreasing the lipid accumulation by individually and iteratively knocking out four...
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