Nature

Consolidated Plasmid Design for Stabilized Heterologous Production of the Complex Natural Product Siderophore Yersiniabactin

7 days ago   |   By Wiley

Abstract
Yersiniabactin is a hybrid polyketide‐nonribosomal complex natural product also known as a siderophore for its iron chelation properties. The native producer of Ybt, Yersinia pestis, is a priority pathogen responsible for the plague in which the siderophore properties of Ybt are used to sequester iron and other metal species upon host infection. Alternatively, the high metal binding properties of Ybt enable a plethora of potentially valuable applications benefiting from metal remediation and/or recovery. For these applications, a surrogate production source is highly preferred...
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