Polymorphisms

A Genome-Wide Study of Single-Nucleotide Polymorphisms in MicroRNAs and Further In Silico Analysis Reveals Their Putative Role in Susceptibility to Late-Onset Alzheimer's Disease

1 month ago   |   By Springer

Abstract
Late-onset Alzheimer's disease is a neurodegenerative disorder of growing relevance in an aging society for which predictive biomarkers are needed. Many genes involved in LOAD are tightly controlled by microRNAs , which can be modulated by single-nucleotide polymorphisms. Our aim was to determine the association between SNPs in miRNAs and LOAD. We selected all SNPs in pre-miRNAs with a minor allele frequency > 1% and genotyped them in a cohort of 229 individuals diagnosed with LOAD and 237 unrelated healthy controls. In silico analyses were performed to predict the effect of SNPs...
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Overexpression of α-Synuclein Reorganises Growth Factor Profile of Human Astrocytes

1 month ago   |   By Springer

Abstract
Misfolding and accumulation of aberrant α-synuclein in the brain is associated with the distinct class of neurodegenerative diseases known as α-synucleinopathies, which include Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Pathological changes in astrocytes contribute to all neurological disorders, and astrocytes are reported to possess α-synuclein inclusions in the context of α-synucleinopathies. Astrocytes are known to express and secrete numerous growth factors, which are fundamental for neuroprotection, synaptic connectivity and brain metabolism...
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The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

1 month ago   |   By Springer

Abstract
Brain-derived neurotrophic factor is a member of the neurotrophin family of growth factors that plays a crucial role in the development of the nervous system while supporting the survival of existing neurons and instigating neurogenesis. Altered levels of BDNF, both in the circulation and in the central nervous system , have been reported to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease , Parkinson's disease , amyotrophic lateral sclerosis , Huntington's disease , multiple sclerosis , and ischemic stroke. MicroRNAs are a class of...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Emergent BioSolutions: Sr. Manager, Analytical Development

Emergent BioSolutions: Those who join Emergent BioSolutions feel a sense of ownership about their future. You will excel in an environment characterized by respect... Read more ...

The Under-explored Extracellular Proteome of Aero-Terrestrial Microalgae...

Abstract Trebouxia sp. and Coccomyxa simplex are desiccation-tolerant lichen microalgae with different adaptive strategies in accordance with the prevailing conditions of their... Read more ...

Systems Integration Team, Staff Scientist - Singular Genomics - San Diego, CA

Singular Genomics is inventing at the forefront of genomics, one of the world's fastest-growing industries. We are a venture-backed biotech company in La Jolla,... From... Read more ...

Walking Faster and Farther With a Soft Robotic Exosuit: Implications for...

Objective: Soft robotic exosuits can improve the mechanics and energetics of walking after stroke. Building on this prior work, we evaluated the effects of the first prototype... Read more ...

Alveolar Tissue Fibers and Surfactant Effects on Lung Mechanics - Model...

Goal: Alveolar compliance is a main determinant of lung airflow. The compliance of the alveoli is a function of their tissue fiber elasticity, fiber volume, and surface... Read more ...

Sub-Nanowatt Ultrasonic Bio-Telemetry Using B-Scan Imaging

Goal: The objective of this paper is to investigate if the use of a B-scan ultrasound imaging system can reduce the energy requirements, and hence the power-dissipation... Read more ...

Face Coverings, Aerosol Dispersion and Mitigation of Virus Transmission Risk

The SARS-CoV-2 virus is primarily transmitted through virus-laden fluid particles ejected from the mouth of infected people. Face covers can mitigate the risk of virus... Read more ...

Neural Implants Without Electronics: A Proof-of-Concept Study on a Human...

Objective: Chronic neural implants require energy and signal supply. The objective of this work was to evaluate a multichannel transcutaneous coupling approach in an ex vivo... Read more ...

Plant genome editing expanded with newly engineered variant of CRISPR-Cas9

Scientists have created a newly engineered variant of the famed gene editing tool CRISPR-Cas9. SpRY removes the barriers of what can and can't be targeted for gene editing... Read more ...

Student uses zebrafish to study spinal deformities

Molecular developmental biologists used zebrafish embryos to study a gene mutation that causes scoliosis, a sideways curvature of the spine that typically occurs in humans just... Read more ...