Gene

The histone methyltransferase inhibitor A-366 enhances hemoglobin expression in erythroleukemia cells upon co‐exposure with chemical inducers in culture

14 days ago   |   By Springer

Abstract
Background
Erythroleukemia is caused by the uncontrolled multiplication of immature erythroid progenitor cells which fail to differentiate into erythrocytes. By directly targeting this class of malignant cells, the induction of terminal erythroid differentiation represents a vital therapeutic strategy for this disease. Erythroid differentiation involves the execution of a well-orchestrated gene expression program in which epigenetic enzymes play critical roles. In order to identify novel epigenetic mediators of differentiation, this study explores the effects of multiple, highly...
Read more ...

 

Differential expression profiles of long noncoding RNAs and mRNAs in human bone marrow mesenchymal stem cells after exposure to a high dosage of dexamethasone

15 days ago   |   By Springer

Abstract
Background
Abnormalities in apoptosis, cell cycle, proliferation, and differentiation of human bone marrow mesenchymal stem cells significantly impact bone metabolism and remodeling, resulting in various skeletal disorders. Long-term exposure to a high dosage of dexamethasone induces apoptosis and inhibits the proliferation of mesenchymal stromal cells , which are probable primary causes of various skeletal disorders. However, to date, the exact mechanisms of action of Dex on hBMSCs have not been fully elucidated.
Methods
To explore the effects of Dex on apoptosis, cell cycle...
Read more ...

 


Search by Tags

   Gene      Chemicals      Chemical      Therapeutics      Genes      Enzymes      Oil  


World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Latin America Expansion

Latin America Expansion

We're growing! At PSC Biotech Corporation, we take great pleasure in announcing that, in light of our remarkable continuous growth over the last several years, we are expanding... Read more ...

Case Study | How Thermo Fisher Scientific Streamlined Inspection Management...

Case Study | How Thermo Fisher Scientific Streamlined Inspection Management With AuditUtopia®

Our Software Solutions Read more ...

How to Find Mutated Sperm? Just Go FISH

How to Find Mutated Sperm? Just Go FISH

Chemotherapy and radiation treatments are known to cause harsh side effects that patients can see or feel throughout their bodies. Yet there are additional, unseen and often... Read more ...

Early breeding reduced harmful mutations in sorghum

When humans first domesticated maize some 9,000 years ago, those early breeding efforts led to an increase in harmful mutations to the crop's genome compared to their wild... Read more ...

High‐capacity Multimodal Anion‐exchange Membranes for Polishing of...

Abstract This contribution reports on a study using Purexa TM ‐MQ multimodal anion‐exchange membranes for protein polishing at elevated solution conductivities. Dynamic binding... Read more ...

Rallybio hires Tuch from BMO to lead corporate development

Rallybio hires Tuch from BMO to lead corporate development ntaylor Thu, 01/21/2021 - 08:25 Read more ...

Servier, MiNA ally to upregulate neurological disorder proteins using small...

Servier, MiNA ally to upregulate neurological disorder proteins using small activating RNAs ntaylor Thu, 01/21/2021 - 07:51 Read more ...

Numerical modeling in arterial hemodynamics incorporating fluid-structure...

The effects of arterial wall compliance on blood flow have been revealed using fluid-structure interaction in last decades. However, microcirculation is not considered in... Read more ...

Correction to: Required concentration index quantifies effective drug...

An amendment to this paper has been published and can be accessed via the original article. Read more ...

Machine Learning in Rheumatic Diseases

Abstract With advances in information technology, the demand for using data science to enhance healthcare and disease management is rapidly increasing. Among these... Read more ...