Immunity

Liraglutide targets the gut microbiota and the intestinal immune system to regulate insulin secretion

10 days ago   |   By Springer

Abstract
Aims
Liraglutide controls type 2 diabetes and inflammation. Gut microbiota regulates the immune system and causes at least in part type 2 diabetes. We here evaluated whether liraglutide regulates T2D through both gut microbiota and immunity in dysmetabolic mice.
Methods
Diet-induced dysmetabolic mice were treated for 14 days with intraperitoneal injection of liraglutide or with vehicle or Exendin 4 as controls. Various metabolic parameters, the intestinal immune cells were characterized and the 16SrDNA gene sequenced from the gut. The causal role of gut microbiota was shown using...
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Modeling and simulation of glucose insulin glucagon algorithm for artificial pancreas to control the diabetes mellitus

10 days ago   |   By Springer

Abstract
Artificial pancreas systems the courage to remove this risk by taking existing pump technology to a new level. In this paper, we modified the existing model for type 1 diabetes mellitus to discuss different control strategies for the artificial pancreas. A model consists of eight states variables and various parameters, numerous of which are undefined and complicated to find out correctly. The stability of glucose-insulin in humans has been created and validated the non-negative unique solution. Controllability and observability for the glucose-insulin system is treated for...
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