Genome

ATAV: a comprehensive platform for population-scale genomic analyses

1 month ago   |   By BMC Bioinformatics

A common approach for sequencing studies is to do joint-calling and store variants of all samples in a single file. If new samples are continually added or controls are re-used for several studies, the cost an...
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Efficient deletion of multiple circle RNA loci by CRISPR‐Cas9 reveals Os06circ02797 as a putative sponge for OsMIR408 in rice

1 month ago   |   By Wiley

Summary
CRISPR‐Cas9 is an emerging genome editing tool for reverse genetics in plants. However, its application for functional study of non‐coding RNAs in plants is still at its infancy. Despite being a major class of non‐coding RNAs, the biological roles of circle RNAs remain largely unknown in plants. Previous plant circRNA studies have focused on identification and annotation of putative circRNAs, with their functions largely uninvestigated by genetic approaches. Here, we applied a multiplexed CRISPR‐Cas9 strategy to efficiently acquire individual null mutants for four circRNAs in rice...
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CRISPR/Cas9‐mediated genome editing of MaACO1 (aminocyclopropane‐1‐carboxylate oxidase 1) promotes the shelf life of banana fruit

1 month ago   |   By Wiley

Plant Biotechnology Journal, EarlyView.
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Simultaneous knock‐out of multiple LHCF genes using single sgRNAs and engineering of a high fidelity Cas9 for precise genome editing in marine algae

1 month ago   |   By Wiley

Abstract
The CRISPR/Cas9 system is an RNA‐guided sequence specific genome editing tool, which has been adopted for single or multiple gene editing in a wide range of organisms. When working with gene families with functional redundancy, knocking out multiple genes within the same family may be required to generate a phenotype. In this study, we tested the possibility of exploiting the known tolerance of Cas9 for mismatches between the single guide RNA and target site to simultaneously introduce indels in multiple homologous genes in the marine diatom Phaeodactylum tricornutum. As a proof...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Susan Bukata, MD, Named Chair of the Department of Orthopaedic Surgery

Bukata is only the fourth woman in the U.S. to lead a health system's orthopedic surgery department. Read more ...

A trait of the rare few whose bodies naturally control HIV: 'trained' immune...

Scientists have discover that 'elite controllers' have myeloid dendritic cells that display characteristics of trained innate immune cells. Read more ...

How mitochondria make the cut

With the help of their custom-built super-resolution microscope, biophysicists have discovered where and why mitochondria divide, putting to rest controversy about the... Read more ...

Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates...

Excessive expression of matrix metalloproteinase 9 impedes healing of diabetic chronic wounds, thus wound dressing that could effectively inhibit the expression of MMP-9 offers... Read more ...

The unpredictable carbon nanotube biocorona and a functionalization method...

The intrinsic physicochemical properties of carbon nanotubes make them unique tools in nanotechnology. Their elemental composition, resilience, thermal properties, and surface... Read more ...

Enhancement of doxorubicin anti-cancer activity by vascular targeting using...

Gold nanospheres tagged with peptides containing isoDGR , an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor... Read more ...

Immune response induced by oral administration with a Saccharomyces...

The global pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 highlights the need to develop safe and effective vaccines with a top... Read more ...

Thin, Large-Area Device Converts Infrared Light into Images

An infrared imager developed by UC San Diego engineers could be used to see through smog and fog; easily locate blood vessels on a patient; and see through silicon wafers to... Read more ...

Blanks for the Memory

UC San Diego researchers report that one kind of perceptual learning can occur in memory-impaired persons who do not actually remember what they learned. Read more ...

Wishbone Day Raises Awareness of Osteogenesis Imperfecta

Today, May 6th, is Wishbone Day , to raise awareness about osteogenesis imperfecta . Also known as “brittle bone disease,” OI is a consequence of mutations that disrupt the... Read more ...