Research
An Evolutionary Profile Guided Greedy Parallel Replica-Exchange Monte Carlo Search Algorithm for Rapid Convergence in Protein Design
5 days ago | By IEEE/ACM
Protein design, also known as the inverse protein folding problem, is the identification of a protein sequence that folds into a target protein structure. Protein design is proved as an NP-hard problem. While researchers are working on designing heuristics with an emphasis on new scoring functions, we propose a replica-exchange Monte Carlo search algorithm that ensures faster convergence using a greedy strategy. Using biological insights, we construct an evolutionary profile to encode the amino acid variability in different positions of the target protein from its structural homologs. The...
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A Novel Branch-and-Bound Algorithm for the Protein Folding Problem in the 3D HP Model
5 days ago | By IEEE/ACM
The protein folding problem is an important issue in bioinformatics and biochemical physics. One of the most widely studied models of protein folding is the hydrophobic-polar model introduced by Dill. The PFP in the three-dimensional lattice HP model has been shown to be NP-complete; the proposed algorithms for solving the problem can therefore only find near-optimal energy structures for most long benchmark sequences within acceptable time periods. In this paper, we propose a novel algorithm based on the branch-and-bound approach to solve the PFP in the 3D lattice HP model. For 10...
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Research Protein Biological Biologic Biology Bioinformatics Bioinformatic Physics Biochemical Energy Computers PaperWorld Biotechnology Congress 2019
Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...
World Biotechnology Congress 2019
Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...
2nd International Conference on Tissue Science and Regenerative Medicine
This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...
Alicia Garza, Black Futures Lab Principal, Black Lives Matter Co-Founder, to...
Author, political strategist and organizer Alicia Garza will serve as keynote speaker at UC San Diego's Commencement 2021 ceremonies, which will be held June 12-13. A UC San... Read more ...
Programming proteins to turn cells into molecular computers
A new method of breaking and fixing proteins could speed the development of sophisticated computer-like circuits in cells that will pave the way to new biotechnology and... Read more ...
Better understanding of fundamental cell behavior can improve drug development
Pioneering research from Vanderbilt scientists shows that cells respond differently to acute stress than to gradual stress. The findings establish an entirely new way to look... Read more ...
New method of artificially creating genetic switches for yeast
A group of researchers from Kobe University and Chiba University has successfully developed a flexible and simple method of artificially producing genetic switches for yeast, a... Read more ...
Bacteria breaking down mountains: Bioleaching to extract ores with less...
How do you break down kilometers of rock to get the metals within? You go small. Bacteria-level small. Read more ...
From Smoky Skies to a Green Horizon: Scientists Convert Fire-Risk Wood into...
Reliance on petroleum fuels and raging wildfires: Two separate, large-scale challenges that could be addressed by one scientific breakthrough. Teams from Lawrence Berkeley... Read more ...
The right to vote is fundamental - a letter from biotechnology industry leaders
We oppose all attempts to introduce laws that reduce the rights of US citizens to vote or that restrict them from exercising that right. The right to vote is fundamental to... Read more ...
Bluebird, PsiOxus show oncolytic virus boosts CAR-T in solid tumors
Bluebird, PsiOxus show oncolytic virus boosts CAR-T in solid tumors ntaylor Wed, 04/14/2021 - 08:44 Read more ...
Bhargava leaves Gilead to take up post at biotech investor MPM
Bhargava leaves Gilead to take up post at biotech investor MPM ntaylor Wed, 04/14/2021 - 07:59 Read more ...
Senti Biosciences in $645M Spark pact to drive gene circuits into the fast lane
Senti Biosciences in $645M Spark pact to drive gene circuits into the fast lane badams Wed, 04/14/2021 - 07:49 Read more ...