Protein

MGlu3 receptor regulates microglial cell reactivity in neonatal rats

12 days ago   |   By Springer

Abstract
Background
Perinatal inflammation is a key factor of brain vulnerability in neonates born preterm or with intra-uterine growth restriction , two leading conditions associated with brain injury and responsible for neurocognitive and behavioral disorders. Systemic inflammation is recognized to activate microglia, known to be the critical modulators of brain vulnerability. Although some evidence supports a role for metabotropic glutamate receptor 3 in modulation of neuroinflammation, its functions are still unknown in the developing microglia.
Methods
We used a double-hit rat model...
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