Protein
Multi‐Step Molecular Mechanism of Amyloid‐Like Aggregation of Nucleic Acid‐Binding Domain of TDP‐43
3 monthes ago | By Wiley
Abstract
TDP-43 protein is associated with many neurodegenerative diseases and has been shown to adopt various oligomeric and fibrillar states. However, a detailed kinetic understanding of the structural transformation of the native form of the protein to the fibrillar state is missing. In this study, we delineate the temporal sequence of structural events during the amyloid-like assembly of the functional nucleic acid-binding domain of TDP-43. We kinetically mapped the aggregation process using multiple probes such as tryptophan and Thioflavin T fluorescence, circular dichroism , and...
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