Bioinformatic

Immunoinformatics prediction of potential immunodominant epitopes from human coronaviruses and association with autoimmunity

15 days ago   |   By Springer

Abstract
Cross-reactivity between different human coronaviruses might contribute to COVID-19 outcomes. Here, we aimed to predict conserved peptides among different HCoVs that could elicit cross-reacting B cell and T cell responses. Three hundred fifty-one full-genome sequences of HCoVs, including SARS-CoV-2 (51), SARS-CoV-1 (50), MERS-CoV (50), and common cold species OC43 (50), NL63 (50), 229E (50), and HKU1 (50) were downloaded aligned using Geneious Prime 20.20. Identification of epitopes in the conserved regions of HCoVs was carried out using the Immune Epitope Database to predict B...
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Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology

15 days ago   |   By Springer

Abstract
Background
Severe Acute Respiratory Syndrome Coronavirus 2 causes coronavirus disease 2019 through direct lysis of infected lung epithelial cells, which releases damage-associated molecular patterns and induces a pro-inflammatory cytokine milieu causing systemic inflammation. Anti-viral and anti-inflammatory agents have shown limited therapeutic efficacy. Soluble CD24 blunts the broad inflammatory response induced by damage-associated molecular patterns via binding to extracellular high mobility group box 1 and heat shock proteins, as well as regulating the downstream Siglec10-Src...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

An unexpected attraction of nucleic acids and fat

All cells on Earth are enveloped in a fatty layer of lipids. Lipid membranes protect the content of the cells, including genetic information such as RNA and DNA. A new study... Read more ...

Designed SARS‐CoV‐2 receptor binding domain variants form stable monomers

Abstract The receptor binding domain of the SARS-CoV-2 spike -protein is a prime target of virus-neutralizing antibodies present in convalescent sera of COVID-19 patients and... Read more ...

Engineering Acetobacterium woodii for the production of isopropanol and...

Abstract The capability of four genetically modified A. woodii strains for improved production of acetone from CO 2 and hydrogen was tested. The acetone biosynthesis pathway... Read more ...

L‐Lactate oxidase‐mediated removal of L‐lactic acid derived from...

Abstract Background : There has been an increasing demand for optically pure D-lactic and L-lactic acid for the production of stereocomplex-type polylactic acid. The D-lactic... Read more ...

Structure‐based discovery of small molecules improving stability of human...

Abstract The production of biopharmaceuticals in engineered plant-based systems is a promising technology that has proven its suitability for the production of various... Read more ...

Leaf Angle: A Target of Genetic Improvement in Cereal Crops Tailored for...

Summary High-density planting is an effective measure for increasing crop yield per unit land area. Leaf angle is a key trait of plant architecture and a target for genetic... Read more ...

Ontology-based identification and prioritization of candidate drugs for...

Drug repurposing can improve the return of investment as it finds new uses for existing drugs. Literature-based analyses exploit factual knowledge on drugs and diseases, e.g... Read more ...

Proliferation and differentiation of primary bovine myoblasts using...

Abstract Recently, cultured meat obtained from livestock-derived cells is being considered as a sustainable food source that reduces the use of natural resources. This study... Read more ...

Novel modified culture medium for enhancing redifferentiation of...

Abstract The dedifferentiation of articular chondrocytes during in vitro expansion deteriorates the hyaline cartilage regeneration. Many approaches have been developed to... Read more ...

UFGI Publication Round-up: Week of 1/24/22

Mitogen-Activated Protein Kinase 4-Regulated Metabolic Networks. Lin C, Lott AA, Zhu W, Dufresne CP, Chen S. Int J Mol Sci. 2022 Jan 14;23(2):880. doi... Read more ...