RESEARCH ARTICLE

Assessing the binding properties of CASP14 targets and models

3 days ago   |   By Wiley

Abstract
An important question is how well the models submitted to CASP retain the properties of target structures. We investigate several properties related to binding. First we explore the binding of small molecules as probes, and count the number of interactions between each residue and such probes, resulting in a binding fingerprint. The similarity between two fingerprints, one for the X-ray structure and the other for a model, is determined by calculating their correlation coefficient. The fingerprint similarity weakly correlates with global measures of accuracy, and GDT TS higher...
Read more ...

 

Assessing the utility of CASP14 models for molecular replacement

3 days ago   |   By Wiley

Abstract
The assessment of CASP models for utility in molecular replacement is a measure of their use in a valuable real-world application. In CASP7, the metric for molecular replacement assessment involved full likelihood-based molecular replacement searches; however, this restricted the assessable targets to crystal structures with only one copy of the target in the asymmetric unit, and to those where the search found the correct pose. In CASP10, full molecular replacement searches were replaced by likelihood-based rigid-body refinement of models superimposed on the target using the LGA...
Read more ...

 


Search by Tags

   RESEARCH ARTICLE  


World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Sr Scientist - Protein Sciences - Novartis / NIBR / GNF / San Diego...

High degree of self-motivation and attention to detail. Support the collection of analytical data. Present scientific and technical work.From Novartis - Sat, 16 Oct 2021... Read more ...

Benchmarking sequencing methods and tools that facilitate the study of...

Alternative cleavage and polyadenylation , an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3′ ends... Read more ...

A global screening identifies chromatin-enriched RNA-binding proteins and...

Cellular RNA-binding proteins have multiple roles in post-transcriptional control, and some are shown to bind DNA. However, the global localization and the general... Read more ...

KrasG12D induces changes in chromatin territories that differentially impact...

Pancreatic ductal adenocarcinoma initiation is most frequently caused by Kras mutations. Read more ...

San Diego biotech veterans launch novel therapeutics firm targeting cancer...

Tentarix comes out of stealth mode, raises $50 million in venture funding led by Versant Ventures, Samsara BioCapital Read more ...

Genetic and process engineering strategies for enhanced recombinant...

The production of N-linked glycoproteins in genetically amenable bacterial hosts offers great potential for reduced cost, faster/simpler bioprocesses, greater customisation... Read more ...

Associate Director/Director Translational Research - Viracta Therapeutics...

5+ years of pharmaceutical or biotechnology industry experience in oncology/cancer immunotherapy. Viracta Therapeutics, a precision oncology company focused on...From Viracta... Read more ...

Long-Term Stable Reduction of Low-Density Lipoprotein in Nonhuman Primates...

Wang, L. et al. Molecular Therapy. 6, 2019-2029 (2021). Read more ...

Mitochondrial Targeted Meganuclease as a Platform to Eliminate Mutant mtDNA...

Zekonyte, U. et al. Nat Commun. 12, 3210 (2021). Read more ...

Scientists map brain circuit that drives activity in fertile females

Scientists have known for a century that female animals become more active just as they are about to ovulate, a behavior that evolved to enhance their chances of mating when... Read more ...