RNA

Lnc-GAN1 expression is associated with good survival and suppresses tumor progression by sponging mir-26a-5p to activate PTEN signaling in non-small cell lung cancer

12 days ago   |   By Springer

Abstract
Background
Long non-coding RNAs play vital roles in the development and progression of non-small-cell lung cancer ; however, the role of most lncRNAs in NSCLC remains unknown. This study explored the clinical significance, biological function and underlying mechanism of lnc-GAN1 in NSCLC.
Methods
With a custom lncRNA microarray we found that lnc-GAN1 is markedly downregulated in NSCLC tissues. Then lnc-GAN1 expression level was measured using qRT-PCR in NSCLC tissues and cell lines. Survival was assessed using the Kaplan-Meier method. The biological functions of lnc-GAN1 in lung...
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Mesenchymal stem cell-derived exosome miR-542-3p suppresses inflammation and prevents cerebral infarction

12 days ago   |   By Springer

Abstract
Background
Cerebral infarction ranks as the second leading cause of disability and death globally, and inflammatory response of glial cells is the main cause of brain damage during cerebral infarction.
Methods
Studies have shown that mesenchymal stem cells can secrete exosomes and contribute to cerebral disease. Here, we would explore the function of MSC-derived exosome in cerebral infarction.
Results
Microarray indicated a decrease of miR-542-3p and an increase of Toll-Like Receptor 4 in middle cerebral artery occlusion mice comparing with sham mice. And luciferase and RIP...
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