Genome

ATAV: a comprehensive platform for population-scale genomic analyses

1 month ago   |   By BMC Bioinformatics

A common approach for sequencing studies is to do joint-calling and store variants of all samples in a single file. If new samples are continually added or controls are re-used for several studies, the cost an...
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Efficient deletion of multiple circle RNA loci by CRISPR‐Cas9 reveals Os06circ02797 as a putative sponge for OsMIR408 in rice

1 month ago   |   By Wiley

Summary
CRISPR‐Cas9 is an emerging genome editing tool for reverse genetics in plants. However, its application for functional study of non‐coding RNAs in plants is still at its infancy. Despite being a major class of non‐coding RNAs, the biological roles of circle RNAs remain largely unknown in plants. Previous plant circRNA studies have focused on identification and annotation of putative circRNAs, with their functions largely uninvestigated by genetic approaches. Here, we applied a multiplexed CRISPR‐Cas9 strategy to efficiently acquire individual null mutants for four circRNAs in rice...
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CRISPR/Cas9‐mediated genome editing of MaACO1 (aminocyclopropane‐1‐carboxylate oxidase 1) promotes the shelf life of banana fruit

1 month ago   |   By Wiley

Plant Biotechnology Journal, EarlyView.
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Simultaneous knock‐out of multiple LHCF genes using single sgRNAs and engineering of a high fidelity Cas9 for precise genome editing in marine algae

1 month ago   |   By Wiley

Abstract
The CRISPR/Cas9 system is an RNA‐guided sequence specific genome editing tool, which has been adopted for single or multiple gene editing in a wide range of organisms. When working with gene families with functional redundancy, knocking out multiple genes within the same family may be required to generate a phenotype. In this study, we tested the possibility of exploiting the known tolerance of Cas9 for mismatches between the single guide RNA and target site to simultaneously introduce indels in multiple homologous genes in the marine diatom Phaeodactylum tricornutum. As a proof...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Process for eliminating unneeded cells may also protect against cancer

Biologists find cell extrusion, a process that helps organisms eliminated unneeded cells, is triggered when cells can't replicate their DNA during cell division. In humans... Read more ...

New bonobo genome fine tunes great ape evolution studies

A new, high-quality bonobo genome assembly has been constructed. It is allowing scientists to more accurately compare the bonobo genome to that of other great apes - the... Read more ...

Director of Finance - Janux Therapeutics, Inc. - San Diego, CA

Janux is developing unique immunotherapies that generate tumor-specific immune responses to attack and kill tumors without destroying a patient's healthy tissue... $47,448... Read more ...

Resident Immune Cells Nurse Brain Cells after Seizure

Resident Immune Cells Nurse Brain Cells after Seizure

Mayo Clinic researchers have found evidence that a type of resident immune cell in the brain helps protect neurons after seizures. Their results, published in Cell Reports... Read more ...

Macrophage Communication is Key During Viral Infection

Macrophage Communication is Key During Viral Infection

A new finding from Mayo Clinic researchers and colleagues may suggest treatment options for severe viral infections and new avenues for research into tissue regeneration after... Read more ...

Expelling cancer by squeezing out rogue cells

Expelling cancer by squeezing out rogue cells aliu Wed, 05/05/2021 - 08:01 Read more ...

CVS now offering walk-in coronavirus vaccination at pharmacies in San Diego...

The pharmacy chain is also offering same-day appointment scheduling Read more ...

Cymbiotika Introduces Rya Organics for Its Market-leading CBD Products

SAN DIEGO-- CBD-Cymbiotika, a leading nutritional supplement brand known for creating pure, clinically backed supplements, announces the launch of Rya Organics. Read more ...

Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole...

1,2,4-oxadiazole derivatives exhibited significant anti-cancer activity when they were evaluated, against human cancer cell lines. They also showed anti-inflammatory... Read more ...

Manager, Site Operations | Astellas

Job Description Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be... Read more ...