Therapies

Changes to culture pH and dissolved oxygen can enhance chimeric antigen receptor T‐cell generation and differentiation

26 days ago   |   By Wiley

Abstract
Chimeric antigen receptor T-cell therapy is growing clinically and commercially as a powerful new approach to treat cancer. Understanding how key culture conditions such as pH and dissolved oxygen affect CAR T-cell generation and function is important in developing better CAR-T manufacturing processes and CAR T-cell therapies for patients. We used the automated mini-bioreactor 15 platform to assess how differences in pH and DO affect CAR T-cell transduction, proliferation, and differentiation. We found that higher pH can significantly improve CAR T-cell transduction and...
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PDGFB targeting biodegradable FePt alloy assembly for MRI guided starvation-enhancing chemodynamic therapy of cancer

26 days ago   |   By Journal of Nanobiotechnology

The application of chemodynamic therapy for cancer is a serious challenge owing to the low efficiency of the Fenton catalyst and insufficient H2O2 expression in cells. Herein, we fabricated a PDGFB targetin...
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World Biotechnology Congress 2019

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