Tissue

Upregulation of long noncoding RNA XIST has anticancer effects on ovarian cancer through sponging miR-106a

15 days ago   |   By Springer

Abstract
Ovarian cancer is a highly malignant tumor. X inactive specific transcript was identified as a cancer-related gene, while its therapeutic effect in OC was poorly defined. The present study was designed to investigate the effectual corollary of the lncRNA XIST in OC. RT-qPCR was used to detect the XIST and miR-106a expression levels of OC tissues and cell lines. OC cell apoptosis and proliferation were detected by flow cytometry, colony formation, and CCK-8 assays. Moreover, bioinformatics analysis was used to predict the targeted miRNA of XIST. The dual-luciferase reporter and RNA...
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An immune-related risk gene signature predicts the prognosis of breast cancer

15 days ago   |   By Springer

Abstract
Background
Accurate prediction of the outcome of breast cancer remains as a challenge due to its heterogeneous nature. We aimed to construct an immune-related risk signature to predict the overall outcome of breast cancer using bioinformatic approaches.
Methods
In this study, transcriptome and survival data obtained from The Cancer Genome Atlas database and the Gene Expression Omnibus database were used to identify differentially expressed genes between breast cancer and normal samples. A regulatory network was constructed based on the immune-related prognostic genes and...
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World Biotechnology Congress 2019

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