Immunity
Hypoxia and the phenomenon of immune exclusion
14 days ago | By Springer
Abstract
Over the last few years, cancer immunotherapy experienced tremendous developments and it is nowadays considered a promising strategy against many types of cancer. However, the exclusion of lymphocytes from the tumor nest is a common phenomenon that limits the efficiency of immunotherapy in solid tumors. Despite several mechanisms proposed during the years to explain the immune excluded phenotype, at present, there is no integrated understanding about the role played by different models of immune exclusion in human cancers. Hypoxia is a hallmark of most solid tumors and, being a...
Read more ...
PPP2R2B downregulation is associated with immune evasion and predicts poor clinical outcomes in triple-negative breast cancer
15 days ago | By Springer
Abstract
Background
Although immune checkpoint blockade has emerged as a novel promising strategy for triple-negative breast cancer , many patients fail response or acquire resistance to current agents. Consequently, our focus need to shift toward alternative inhibitory targets, predictor for responsiveness, and immune suppressive mechanisms.
Methods
In this study, we performed systematic bioinformatics analyses to identify PPP2R2B as a robust tumor suppressor in TNBC. Meanwhile, breast cancer progression cell line model was applied in our research. Quantitative real-time PCR assay was...
Read more ...
Search by Tags
Immunity Biology Biologic Biological Cancer Genes Gene Tissue Genome Genomics Bioinformatics Research Bioinformatic Applied ClinicalWorld Biotechnology Congress 2019
Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...
World Biotechnology Congress 2019
Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...
2nd International Conference on Tissue Science and Regenerative Medicine
This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...
Latin America Expansion
We're growing! At PSC Biotech Corporation, we take great pleasure in announcing that, in light of our remarkable continuous growth over the last several years, we are expanding... Read more ...
Case Study | How Thermo Fisher Scientific Streamlined Inspection Management...
Our Software Solutions Read more ...
How to Find Mutated Sperm? Just Go FISH
Chemotherapy and radiation treatments are known to cause harsh side effects that patients can see or feel throughout their bodies. Yet there are additional, unseen and often... Read more ...
Early breeding reduced harmful mutations in sorghum
When humans first domesticated maize some 9,000 years ago, those early breeding efforts led to an increase in harmful mutations to the crop's genome compared to their wild... Read more ...
High‐capacity Multimodal Anion‐exchange Membranes for Polishing of...
Abstract This contribution reports on a study using Purexa TM ‐MQ multimodal anion‐exchange membranes for protein polishing at elevated solution conductivities. Dynamic binding... Read more ...
Rallybio hires Tuch from BMO to lead corporate development
Rallybio hires Tuch from BMO to lead corporate development ntaylor Thu, 01/21/2021 - 08:25 Read more ...
Servier, MiNA ally to upregulate neurological disorder proteins using small...
Servier, MiNA ally to upregulate neurological disorder proteins using small activating RNAs ntaylor Thu, 01/21/2021 - 07:51 Read more ...
Numerical modeling in arterial hemodynamics incorporating fluid-structure...
The effects of arterial wall compliance on blood flow have been revealed using fluid-structure interaction in last decades. However, microcirculation is not considered in... Read more ...
Correction to: Required concentration index quantifies effective drug...
An amendment to this paper has been published and can be accessed via the original article. Read more ...
Machine Learning in Rheumatic Diseases
Abstract With advances in information technology, the demand for using data science to enhance healthcare and disease management is rapidly increasing. Among these... Read more ...