Tissue

Small Heat Shock Protein's Gene Expression Response to Iron Oxide Nanoparticles in the Brain

2 monthes ago   |   By Springer

Abstract
Small heat shock proteins are conserved proteins that participate in many cellular functions like preventing protein aggregation and stress response. However, their role in responding to nanoparticles has not yet been explained. We used a chicken embryo model to investigate the effects of two different forms of iron oxide-NPs on the mRNA expression of HSPB1 , HSPB5 , HSPB8, and HSPB9 in cerebral tissue. Two hundred-ten fertilized eggs were randomly divided into seven groups. Three groups received 100 ppm, 250 ppm, and 500 ppm of Fe 2 O 3 -NPs, respectively. Three other groups...
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The Prospective Ameliorative Role of Zinc Oxide Nanoparticles in STZ-Induced Diabetic Nephropathy in Rats: Mechanistic Targeting of Autophagy and Regulating Nrf2/TXNIP/NLRP3 Inflammasome Signaling

2 monthes ago   |   By Springer

Abstract
Diabetic nephropathy as one of the common microvascular complications of diabetes mellitus, is the main cause of end-stage renal disease. Zinc oxide nanoparticles have been employed in several biomedical aspects. This study purposed to explore the mechanistic renoprotective effects of ZnO NPs in STZ-induced DN. Sixty male Wistar rats were allocated into four equal groups: control, ZnO NPs control, STZ, and STZ + ZnO NPs groups. At the end of the experiment, blood and urine biochemical parameters were assayed. Renal tissue level of advanced glycation end products was assayed...
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