CURRENT SEQUENCE-BASED MODELS CAPTURE GENE EXPRESSION DETERMINANTS IN PROMOTERS BUT MOSTLY IGNORE DISTAL ENHANCERS
The largest sequence-based models of transcription control to date are obtained by predicting genome-wide gene regulatory assays across...
UNCOVERING GENE-FAMILY FOUNDER EVENTS DURING MAJOR EVOLUTIONARY TRANSITIONS IN ANIMALS, PLANTS AND FUNGI USING GENERA
We present GenEra , a DIAMOND-fueled gene-family founder inference framework that addresses previously raised limitations a...
A ROLE FOR HERITABLE TRANSCRIPTOMIC VARIATION IN MAIZE ADAPTATION TO TEMPERATE ENVIRONMENTS
Transcription bridges genetic information and phenotypes. Here, we evaluated how changes in transcriptional regulation enable maize...
MULTI-OMICS ANALYSIS IDENTIFIES DRIVERS OF PROTEIN PHOSPHORYLATION
Phosphorylation of proteins is a key step in the regulation of many cellular processes including activation of enzymes and signaling...
EVIDENCE FOR THE ROLE OF TRANSCRIPTION FACTORS IN THE CO-TRANSCRIPTIONAL REGULATION OF INTRON RETENTION
Alternative splicing is a widespread regulatory phenomenon that enables a single gene to produce multiple transcripts. Among the different...
NOME-HIC: JOINT PROFILING OF GENETIC VARIANT, DNA METHYLATION, CHROMATIN ACCESSIBILITY, AND 3D GENOME IN THE SAME DNA MOLECULE
Cis-regulatory elements are coordinated to regulate the expression of their targeted genes. However, the joint measurement of cis-regulatory...
CONSERVATION AND DIVERGENCE OF CANONICAL AND NON-CANONICAL IMPRINTING IN MURIDS
Genomic imprinting affects gene expression in a parent-of-origin manner and has a profound impact on complex traits including growth...
CELL-SPECIFIC CLOCK-CONTROLLED GENE EXPRESSION PROGRAM REGULATES RHYTHMIC FIBER CELL GROWTH IN COTTON
The epidermis of cotton ovule produces fibers, the most important natural cellulose source for the global textile industry. However,...
THE P323L SUBSTITUTION IN THE SARS-COV-2 POLYMERASE CONFERS A SELECTIVE ADVANTAGE DURING INFECTION
The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the...
EXTENSIVE SEQUENCE DUPLICATION IN ARABIDOPSIS REVEALED BY PSEUDO-HETEROZYGOSITY
It is apparent that genomes harbor much structural variation that is largely undetected for technical reasons. Such variation can cause...
THE NETWORK ZOO: A MULTILINGUAL PACKAGE FOR THE INFERENCE AND ANALYSIS OF GENE REGULATORY NETWORKS
Inference and analysis of gene regulatory networks require software that integrates multi-omic data from various sources. The Network...
GENETIC MAPPING AND MOLECULAR MECHANISM BEHIND COLOR VARIATION IN THE ASIAN VINE SNAKE
Reptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However, the molecular basis...
MULTI-ANCESTRY PHENOME-WIDE ASSOCIATION OF COMPLEMENT COMPONENT 4 VARIATION WITH PSYCHIATRIC AND BRAIN PHENOTYPES IN YOUTH
Increased expression of the complement component 4A gene is associated with a greater lifetime risk of schizophrenia. In the brain,...
RECENT ADVANCES IN THE PLANT EPITRANSCRIPTOME
Chemical modifications of RNAs, known as the epitranscriptome, are emerging as widespread regulatory mechanisms underlying gene regulation....
SRTSIM: SPATIAL PATTERN PRESERVING SIMULATIONS FOR SPATIALLY RESOLVED TRANSCRIPTOMICS
Spatially resolved transcriptomics -specific computational methods are often developed, tested, validated, and evaluated in silico...
WIDESPREAD ALLELE-SPECIFIC TOPOLOGICAL DOMAINS IN THE HUMAN GENOME ARE NOT CONFINED TO IMPRINTED GENE CLUSTERS
There is widespread interest in the three-dimensional chromatin conformation of the genome and its impact on gene expression. However,...
LOSS OF MLL3/4 DECOUPLES ENHANCER H3K4 MONOMETHYLATION, H3K27 ACETYLATION, AND GENE ACTIVATION DURING EMBRYONIC STEM CELL DIFFERENTIATION
Enhancers are essential in defining cell fates through the control of cell-type-specific gene expression. Enhancer activation is a...
CEDAR: INCORPORATING CELL TYPE HIERARCHY IMPROVES CELL TYPE-SPECIFIC DIFFERENTIAL ANALYSES IN BULK OMICS DATA
Bulk high-throughput omics data contain signals from a mixture of cell types. Recent developments of deconvolution methods facilitate...
CORRECTKIN: AN OPTIMIZED METHOD TO INFER RELATEDNESS UP TO THE 4TH DEGREE FROM LOW-COVERAGE ANCIENT HUMAN GENOMES
Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose...
USING PROTEIN-PER-MRNA DIFFERENCES AMONG HUMAN TISSUES IN CODON OPTIMIZATION
Codon usage and nucleotide composition of coding sequences have profound effects on protein expression. However, while it is recognized...
World Biotechnology Congress 2019
Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...
World Biotechnology Congress 2019
Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...
2nd International Conference on Tissue Science and Regenerative Medicine
This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...
A Braver New World? Of chatbots and other cognoscenti
DNA Data Storage Alliance Announces Board Appointments
SAN DIEGO--The DNA Data Storage Alliance, a SNIA Technology Affiliate, formed in 2020 by Illumina, Inc. , Microsoft , Twist Bioscience Corporation and Western Digital to create... Read more ...
Procurement Program Manager - Thermo Fisher Scientific - Carlsbad, CA
Implements effective communication plans and delivers presentations on key initiatives, provides critical implementation updates, delivering value within the...From Thermo... Read more ...
Wugen to Present Data on WU-NK-101 at the American Association for Cancer...
ST. LOUIS & SAN DIEGO--Wugen, Inc., a clinical-stage biotechnology company developing a pipeline of allogeneic cell therapies to treat a broad range of hematological and solid... Read more ...
Quality Engineer - Biotechnology Research - Tektree LLC - Carlsbad, CA
Participate in and author sampling plan development and data analysis for design verification, new/existing product test methods and incoming inspection;... Read more ...
ComparePD: Improving protein-DNA complex model comparison with hydrogen bond...
Abstract Computational modeling of protein-DNA complex structures has important implications in biomedical applications such as structure-based, computer aided drug design. A... Read more ...
The Secret to Writing Successful Grant Proposals
Grant writing aims to prepare and submit a proposal to request funding from a grant-making organization, such as a government agency, private foundation, or corporation. Grant... Read more ...
Project Director - CRB - San Diego, CA
Intermediate understanding of all core engineering disciplines, project execution, delivery in a design and construction. $164,600 - $263,300 a yearFrom... Read more ...
Comparative study of acid- and alkali-catalyzed 1,4-butanediol pretreatment...
Organosolv pretreatment is one of the most efficient methods for delignification and boosting biomass saccharification. As compared to typical ethanol organosolv pretreatments... Read more ...
Marketing Operations Manager - Neurocrine Bioscience - San Diego, CA
Administers the promotional and medical review systems and provides day-to-day system support to users. $123,700... Read more ...