LOOP PATHWAYS ARE RESPONSIBLE FOR TUNING THE ACCUMULATION OF C19- AND C22-STEROL INTERMEDIATES IN THE MYCOBACTERIAL PHYTOSTEROL DEGRADATION PATHWAY
4-Androstene-3,17-dione and 22-hydroxy-23,24-bisnorchol-4-ene-3-one are the most important and representative C19- and C22-steroidal...
MICROBIAL CELL FACTORIES BASED ON FILAMENTOUS BACTERIA, YEASTS, AND FUNGI
Advanced DNA synthesis, biosensor assembly, and genetic circuit development in synthetic biology and metabolic engineering have reinforced...
SIMULTANEOUS ENZYME PRODUCTION, LEVAN-TYPE FOS SYNTHESIS AND SUGAR BY-PRODUCTS ELIMINATION USING A RECOMBINANT PICHIA PASTORIS STRAIN EXPRESSING A LEVANSUCRASE-ENDOLEVANASE FUSION ENZYME
Although Levan-type fructooligosaccharides have been shown to exhibit prebiotic properties, no efficient methods for their large-scale...
EFFICIENT PRODUCTION OF CEMBRATRIENE-OL IN ESCHERICHIA COLI VIA SYSTEMATIC OPTIMIZATION
The tobacco leaf-derived cembratriene-ol exhibits anti-insect effects, but its content in plants is scarce. Cembratriene-ol is difficult...
INVERT EMULSIONS ALLEVIATE BIOTIC INTERACTIONS IN BACTERIAL MIXED CULTURE
The large application potential of microbiomes has led to a great need for mixed culture methods. However, microbial interactions can...
IMPROVING SPINOSAD PRODUCTION BY TUNING EXPRESSIONS OF THE FOROSAMINE METHYLTRANSFERASE AND THE FOROSAMINYL TRANSFERASE TO REDUCE UNDESIRED LESS ACTIVE BYPRODUCTS IN THE HETEROLOGOUS HOST STREPTOMYCES ALBUS J1074
Spinosad is a macrolide insecticide with the tetracyclic lactone backbone to which forosamine and tri-o-methylrhamnose are attached....
INCREASING CELLULAR FITNESS AND PRODUCT YIELDS IN PSEUDOMONAS PUTIDA THROUGH AN ENGINEERED PHOSPHOKETOLASE SHUNT
Pseudomonas putida has received increasing interest as a cell factory due to its remarkable features such as fast growth, a versatile...
NOVEL CONTEXT-SPECIFIC GENOME-SCALE MODELLING EXPLORES THE POTENTIAL OF TRIACYLGLYCEROL PRODUCTION BY CHLAMYDOMONAS REINHARDTII
Gene expression data of cell cultures is commonly measured in biological and medical studies to understand cellular decision-making...
METABOLIC STRESS CONSTRAINS MICROBIAL L-CYSTEINE PRODUCTION IN ESCHERICHIA COLI BY ACCELERATING TRANSPOSITION THROUGH MOBILE GENETIC ELEMENTS
L-cysteine is an essential chemical building block in the pharmaceutical-, cosmetic-, food and agricultural sector. Conventionally,...
INCREASING THE PRODUCTION OF THE BIOACTIVE COMPOUNDS IN MEDICINAL MUSHROOMS: AN OMICS PERSPECTIVE
Macroscopic fungi, mainly higher basidiomycetes and some ascomycetes, are considered medicinal mushrooms and have long been used in...
EXPRESSION OF GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE INCREASES NON-POLAR LIPID ACCUMULATION IN NANNOCHLOROPSIS OCEANICA
Microalgae are considered a suitable production platform for high-value lipids and oleochemicals. Several species including Nannochloropsis...
EFFICIENT RECOMBINANT PRODUCTION OF MOUSE-DERIVED CRYPTDIN FAMILY PEPTIDES BY A NOVEL FACILITATION STRATEGY FOR INCLUSION BODY FORMATION
A number of antimicrobial peptides hold promise as new drugs owing to their potent bactericidal activity and because they are often...
BIDIRECTIONAL HYBRID ERYTHRITOL-INDUCIBLE PROMOTER FOR SYNTHETIC BIOLOGY IN YARROWIA LIPOLYTICA
The oleaginous yeast Yarrowia lipolytica is increasingly used as a chassis strain for generating bioproducts. Several hybrid promoters...
PURIFICATION, CHARACTERIZATION AND ANTICANCER ACTIVITY OF L-METHIONINE Γ-LYASE FROM THERMO-TOLERANT ASPERGILLUS FUMIGATUS
Purification of L-methionine γ-lyase from A. fumigatus was sequentially conducted using heat treatment and gel filtration, resulting...
GOLGI FUCOSYLTRANSFERASE 1 REVEALS ITS IMPORTANT ROLE IN Α-1,4-FUCOSE MODIFICATION OF N-GLYCAN IN CRISPR/CAS9 DIATOM PHAEODACTYLUM TRICORNUTUM
Phaeodactylum tricornutum is a critical microbial cell factory to produce a wide spectrum of marketable products including recombinant...
ENHANCED PRODUCTION OF D-PANTOTHENIC ACID IN CORYNEBACTERIUM GLUTAMICUM USING AN EFFICIENT CRISPR-CPF1 GENOME EDITING METHOD
Corynebacterium glutamicum has industrial track records for producing a variety of valuable products such as amino acids. Although...
PRODUCTION AND BIOPROCESSING OF CAMPTOTHECIN FROM ASPERGILLUS TERREUS, AN ENDOPHYTE OF CESTRUM PARQUI, RESTORING THEIR BIOSYNTHETIC POTENCY BY CITRUS LIMONUM PEEL EXTRACTS
The metabolic potency of fungi as camptothecin producer elevates their prospective use as an industrial platform for commercial production,...
NONRIBOSOMAL ANTIBACTERIAL PEPTIDES ISOLATED FROM STREPTOMYCES AGGLOMERATUS 5-1-3 IN THE QINGHAI-TIBET PLATEAU
New antibiotics are urgently needed in clinical treatment of superdrug-resistant bacteria. Nonribosomal peptides are a major source...
DETECTION OF HUMAN ANNEXIN A1 AS THE NOVEL N-TERMINAL TAG FOR SEPARATION AND PURIFICATION HANDLE
Several fusion tags for separation handle have been developed, but the fused tag for simply and cheaply separating the target protein...
PURIFICATION AND BIOCHEMICAL CHARACTERIZATION OF TWO LACCASE ISOENZYMES ISOLATED FROM TRICHODERMA HARZIANUM S7113 AND ITS APPLICATION FOR BISPHENOL A DEGRADATION
Two laccase isoenzymes were isolated from a novel Trichoderma harzianum S7113 isolate employing ammonium sulfate precipitation, Sephadex...
World Biotechnology Congress 2019
Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...
World Biotechnology Congress 2019
Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...
2nd International Conference on Tissue Science and Regenerative Medicine
This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...
Scientists are trying to resurrect the dodo centuries after the bird...
The list of extinct species that genetic engineering company Colossal wants to bring back to life is growing. The latest addition: the dodo. Read more ...
Six Berkeley Lab Scientists Named AAAS Fellows
New software enables automated analysis of biomedical image data without...
The software JIPipe was developed by scientists at the Leibniz Institute for Natural Product Research and Infection Biology and significantly simplifies the analysis of images... Read more ...
Changes in hippocampal volume during a preceding 10-year period do not...
Abstract Hippocampal blood-brain barrier permeability may increase in normal healthy ageing and contribute to neurodegenerative disease. To examine this hypothesis, we... Read more ...
Morusin and mulberrin extend the lifespans of yeast and C. elegans via...
Abstract Compounds with lifespan extension activity are rare, although increasing research efforts have been invested in this field to find ways to extend healthy lifespan. By... Read more ...
GENTLE: a novel bioinformatics tool for generating features and building...
In the global effort to discover biomarkers for cancer prognosis, prediction tools have become essential resources. TCR repertoires contain important features that... Read more ...
NAD+ supplementation improves mAb productivity in CHO cells via a glucose...
Abstract Aerobic glycolysis and its by-product lactate accumulation are usually associated with adverse culture phenotypes such as poor cell viability and productivity. Due to... Read more ...
BSN 2023 - Call for Papers is Open!
Associations between physical activity and cognitive dysfunction in older...
Abstract Canine cognitive dysfunction is a form of dementia that shares many similarities with Alzheimer's disease. Given that physical activity is believed to reduce risk of... Read more ...
Xylotrechus smei : a potential threat to red sanders cultivation
Abstract Red sanders is an economically important, endangered timber species endemic to the restricted forest tracts of the Eastern Ghats, India. Here, we report the occurrence... Read more ...