INSIGHTS INTO MODULAR POLYKETIDE SYNTHASE LOOPS AIDED BY REPETITIVE SEQUENCES

ABSTRACT The loops of modular polyketide synthases serve diverse functions but are largely uncharacterized. They frequently contain...

SEQUENCE AND EVOLUTIONARY ANALYSIS OF BACTERIAL RIBOSOMAL S1 PROTEINS

ABSTRACT The multi‐domain bacterial S1 protein is the largest and most functionally important ribosomal protein of the 30S subunit,...

 
 
 

VVHDZ28 POSITIVELY REGULATE SA BIOSYNTHESIS DURING SEED ABORTION IN THOMPSON SEEDLESS

Summary Seedlessness in grapes is one of the features most appreciated by consumers. However, the mechanisms underlying seedlessness...

PLANT‐BASED PRODUCTION CAN RESULT IN COVALENT CROSS‐LINKING OF PROTEINS

Abstract Antibodies, antigens, enzymes for replacement therapies and virus‐like particles have all been produced successfully in plants...

 
 
 

EXPERT OPINIONS ON THE REGULATION OF PLANT GENOME EDITING

Summary Global food security is largely affected by factors such as: environmental , social , socio‐economic and health. In response,...

CATALYTIC AND STRUCTURAL PROPERTIES OF ATP‐DEPENDENT CAPROLACTAMASE FROM PSEUDOMONAS JESSENII

Abstract Caprolactamase is the first enzyme in the caprolactam degradation pathway of Pseudomonas jessenii. It is composed of two subunits...

 
 
 

CHOK1SV GS‐KO SSI EXPRESSION SYSTEM: A COMBINATION OF THE FER1L4 LOCUS AND GLUTAMINE SYNTHETASE SELECTION

Abstract There are an ever‐increasing number of biopharmaceutical candidates in clinical trials fueling an urgent need to streamline...

CURRENT STANDARDS AND PITFALLS ASSOCIATED WITH THE TRANSFECTION OF PRIMARY FIBROBLAST CELLS

Abstract Cultured fibroblast cells, especially dermal cells, are used for various types of scientific research, particularly within...

 
 
 

MICROBIOREACTOR‐ASSISTED CULTIVATION WORKFLOWS FOR TIME‐EFFICIENT PHENOTYPING OF PROTEIN PRODUCING ASPERGILLUS NIGER IN BATCH AND FED‐BATCH MODE

Abstract In recent years, many fungal genomes have become publicly available. In combination with novel gene editing tools, this allows...

INTRODUCTION AND CLEARANCE OF BETA‐GLUCAN IN THE DOWNSTREAM PROCESSING OF MONOCLONAL ANTIBODIES

Abstract β‐Glucan process‐related impurities can be introduced into biopharmaceutical products via upstream or downstream processing...

 
 
 

INTERACTION OF LEACHABLE MODEL COMPOUNDS AND THEIR IMPACT ON CHINESE HAMSTER OVARY CELL CULTIVATION

Abstract The presence of leachables in biopharmaceutical processes using single‐use technologies is well known. For the detection and...

DEVELOPMENT OF AN ACTIVATED CARBON FILTRATION STEP AND HIGH THROUGHPUT SCREENING METHOD TO REMOVE HOST CELL PROTEINS FROM A RECOMBINANT ENZYME PROCESS

Abstract An increasing number of non‐mAb recombinant proteins are being developed today. These biotherapeutics provide greater purification...

 
 
 

EXPRESSION OF NLRP3 INFLAMMASOME PROTEINS IN EXPICHO‐S MAMMALIAN CELLS REVEALS OLIGOMERIZATION PROPERTIES THAT ARE HIGHLY SENSITIVE TO SOLUTION CONDITIONS

ABSTRACT The NLRP3 inflammasome is a key intracellular component of the innate immune response. It is a 3‐protein complex essential...

CHARACTERIZATION OF SOY PROTEIN HYDROLYSATES AND INFLUENCE OF ITS IRON CONTENT ON MONOCLONAL ANTIBODY PRODUCTION BY A MURINE HYBRIDOMA CELL LINE

Abstract A challenging aspect with the use of protein hydrolysates in commercial manufacturing processes of recombinant therapeutic...

 
 
 

APPLICATIONS OF FLOW CYTOMETRY SORTING IN THE PHARMACEUTICAL INDUSTRY: A REVIEW

Abstract The article reviews applications of flow cytometry sorting in manufacturing of pharmaceuticals. Flow cytometry sorting is...

Outside Front Cover:

OUTSIDE FRONT COVER:

Cover Image © Natali Mis/Shutterstock

 
 
 

EDITORIAL BOARD: BIOTECHNOLOGY JOURNAL 4/2021

Biotechnology Journal, Volume 16, Issue 4, April 2021.

SURFACE ENGINEERING OF BIOMATERIALS IN ORTHOPEDIC AND DENTAL IMPLANTS: STRATEGIES TO IMPROVE OSTEOINTEGRATION, BACTERIOSTATIC AND BACTERICIDAL ACTIVITIES

Abstract Background The success of biomedical implants in orthopedic and dental applications are usually limited due to insufficient...

 
 
 

SYNTHETIC LOGIC CIRCUITS USING RNA APTAMER AGAINST T7 RNA POLYMERASE

Abstract Recent advances in nucleic acids engineering introduced several RNA‐based regulatory components for synthetic gene circuits,...

EXPRESSION OF NLRP3 INFLAMMASOME PROTEINS IN EXPICHO‐S MAMMALIAN CELLS REVEALS OLIGOMERIZATION PROPERTIES THAT ARE HIGHLY SENSITIVE TO SOLUTION CONDITIONS

ABSTRACT The NLRP3 inflammasome is a key intracellular component of the innate immune response. It is a 3‐protein complex essential...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Alicia Garza, Black Futures Lab Principal, Black Lives Matter Co-Founder, to...

Alicia Garza, Black Futures Lab Principal, Black Lives Matter Co-Founder, to Speak at Commencement

Author, political strategist and organizer Alicia Garza will serve as keynote speaker at UC San Diego's Commencement 2021 ceremonies, which will be held June 12-13. A UC San... Read more ...

Programming proteins to turn cells into molecular computers

A new method of breaking and fixing proteins could speed the development of sophisticated computer-like circuits in cells that will pave the way to new biotechnology and... Read more ...

Better understanding of fundamental cell behavior can improve drug development

Pioneering research from Vanderbilt scientists shows that cells respond differently to acute stress than to gradual stress. The findings establish an entirely new way to look... Read more ...

New method of artificially creating genetic switches for yeast

A group of researchers from Kobe University and Chiba University has successfully developed a flexible and simple method of artificially producing genetic switches for yeast, a... Read more ...

Bacteria breaking down mountains: Bioleaching to extract ores with less...

How do you break down kilometers of rock to get the metals within? You go small. Bacteria-level small. Read more ...

From Smoky Skies to a Green Horizon: Scientists Convert Fire-Risk Wood into...

From Smoky Skies to a Green Horizon: Scientists Convert Fire-Risk Wood into Biofuel

Reliance on petroleum fuels and raging wildfires: Two separate, large-scale challenges that could be addressed by one scientific breakthrough. Teams from Lawrence Berkeley... Read more ...

The right to vote is fundamental - a letter from biotechnology industry leaders

We oppose all attempts to introduce laws that reduce the rights of US citizens to vote or that restrict them from exercising that right. The right to vote is fundamental to... Read more ...

Bluebird, PsiOxus show oncolytic virus boosts CAR-T in solid tumors

Bluebird, PsiOxus show oncolytic virus boosts CAR-T in solid tumors ntaylor Wed, 04/14/2021 - 08:44 Read more ...

Bhargava leaves Gilead to take up post at biotech investor MPM

Bhargava leaves Gilead to take up post at biotech investor MPM ntaylor Wed, 04/14/2021 - 07:59 Read more ...

Senti Biosciences in $645M Spark pact to drive gene circuits into the fast lane

Senti Biosciences in $645M Spark pact to drive gene circuits into the fast lane badams Wed, 04/14/2021 - 07:49 Read more ...