Virus

Molecular dynamics analysis of a flexible loop at the binding interface of the SARS‐CoV‐2 spike protein receptor‐binding domain

3 days ago   |   By Wiley

Abstract
Since the identification of the SARS-CoV-2 virus as the causative agent of the current COVID-19 pandemic, considerable effort has been spent characterizing the interaction between the Spike protein receptor-binding domain and the human angiotensin converting enzyme 2 receptor. This has provided a detailed picture of the end point structure of the RBD-ACE2 binding event, but what remains to be elucidated is the conformation and dynamics of the RBD prior to its interaction with ACE2. In this work, we utilize molecular dynamics simulations to probe the flexibility and conformational...
Read more ...

 

Crystal‐Structures‐Guided Design of Fragment‐Based Drugs for Inhibiting the Main Protease of SARS‐CoV‐2

3 days ago   |   By Wiley

Abstract
Since the beginning of the COVID-19 pandemic, scientists across the globe are racing to find a cure for the highly contagious infectious disease caused by the SARS-CoV-2 virus. Despite many promising ongoing progress, there are currently no FDA approved drug to treat infected patients. Recently, the crowdsourcing of drug discovery for inhibiting the main protease of SARS-CoV-2 have yielded a plenty of drug fragments resolved inside the active site of Mpro via the crystallography method. Following the principle of fragment-based drug design , we are motivated to design a potent...
Read more ...

 


Search by Tags

   Virus      Protein      Enzymes      RESEARCH ARTICLE      Drug      Drugs      Discovery      Energy  


World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Cellular environments shape molecular architecture

An important cellular structure called the nuclear pore complex has larger dimensions than previously thought. A research team made this discovery using cryo-focused ion beam... Read more ...

Sr Scientist - Protein Sciences - Novartis / NIBR / GNF / San Diego...

High degree of self-motivation and attention to detail. Support the collection of analytical data. Present scientific and technical work.From Novartis - Sat, 16 Oct 2021... Read more ...

Benchmarking sequencing methods and tools that facilitate the study of...

Alternative cleavage and polyadenylation , an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3′ ends... Read more ...

A global screening identifies chromatin-enriched RNA-binding proteins and...

Cellular RNA-binding proteins have multiple roles in post-transcriptional control, and some are shown to bind DNA. However, the global localization and the general... Read more ...

KrasG12D induces changes in chromatin territories that differentially impact...

Pancreatic ductal adenocarcinoma initiation is most frequently caused by Kras mutations. Read more ...

San Diego biotech veterans launch novel therapeutics firm targeting cancer...

Tentarix comes out of stealth mode, raises $50 million in venture funding led by Versant Ventures, Samsara BioCapital Read more ...

Genetic and process engineering strategies for enhanced recombinant...

The production of N-linked glycoproteins in genetically amenable bacterial hosts offers great potential for reduced cost, faster/simpler bioprocesses, greater customisation... Read more ...

Associate Director/Director Translational Research - Viracta Therapeutics...

5+ years of pharmaceutical or biotechnology industry experience in oncology/cancer immunotherapy. Viracta Therapeutics, a precision oncology company focused on...From Viracta... Read more ...

Long-Term Stable Reduction of Low-Density Lipoprotein in Nonhuman Primates...

Wang, L. et al. Molecular Therapy. 6, 2019-2029 (2021). Read more ...

Mitochondrial Targeted Meganuclease as a Platform to Eliminate Mutant mtDNA...

Zekonyte, U. et al. Nat Commun. 12, 3210 (2021). Read more ...