Virus

Why are ACE2 binding coronavirus strains SARS‐CoV/SARS‐CoV‐2 wild and NL63 mild?

13 days ago   |   By Wiley

ABSTRACT
Coronaviruses are responsible for several epidemics, including the 2002 SARS, 2012 MERS and COVID‐19. The emergence of recent COVID‐19 pandemic due to SARS‐CoV‐2 virus in December 2019 has resulted in considerable research efforts to design antiviral drugs and other therapeutics against coronaviruses. In this context, it is crucial to understand the biophysical and structural features of the major proteins that are involved in virus‐host interactions. In the current study, we have compared spike proteins from three strains of coronaviruses NL63, SARS‐CoV and SARS‐CoV, known to...
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