Clinical

Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study

25 minutes ago   |   Springer

Abstract Pineoblastomas are rare, aggressive pediatric brain tumors of the pineal gland with modest overall survival despite intensive therapy. We sought to define the clinical...
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SPG8 mutations in Italian families: clinical data and literature review

6 hours ago   |   Springer

Abstract Background Spastic paraplegia type 8 is an autosomal-dominant form of hereditary spastic paraplegia caused by a mutation in the KIAA0196 gene. SPG8 accounts for 1% of...
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ASH: Eli Lilly plots 'ambitious' cancer program after sharing early BTK data

9 hours ago   |   Fierce Biotech

Eli Lilly shared early clinical data on the BTK inhibitor it acquired with Loxo Oncology-and the numbers are strong enough to prompt some action. Most of the heavily pretreated...
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Clinical Trial Administrator - Xencor - San Diego, CA

1 day ago   |   San Diego Biotechnology   |   2 articles

Xencor is an innovative, clinical-stage biotechnology company located in the Los Angeles area and in San Diego.From Xencor - Sat, 07 Dec 2019 15:25:59 GMT - View all San Diego...
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AveXis Inc.: Senior Scientist, Analytical Chemistry

1 day ago   |   San Diego Biotechnology   |   5 articles

AveXis Inc.: OverviewReady to join a team committed to moving gene therapies into the clinical and commercial settings for patients and families devastated by rare San Diego...
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3 Takeaways From the Resurrection of Biogen's Alzheimer's Drug

3 Takeaways From the Resurrection of Biogen's Alzheimer's Drug

2 days ago   |   Xconomy

The name of the experimental drug was heard so frequently in hotel hallways at the conference that it sounded like an incantation: aducanumab, aducanumab, aducanumab...
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FDA Puts Partial Hold on Tests of Ipsen Drug Acquired in $1B Deal

FDA Puts Partial Hold on Tests of Ipsen Drug Acquired in $1B Deal

2 days ago   |   Xconomy

Two clinical trials testing an Ipsen drug in rare connective tissue disorders have been placed on partial hold after safety concerns about chronic dosing of the compound...
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Acadia Looks to Expand Drug Beyond Parkinson's Disease Psychosis

Acadia Looks to Expand Drug Beyond Parkinson's Disease Psychosis

2 days ago   |   Xconomy

Acadia Pharmaceuticals revealed late-stage clinical data this week that could support bringing its drug for psychosis to a broader group of patients. The Acadia drug...
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Advancing functional and translational microbiome research using meta-omics approaches

2 days ago   |   Springer

Abstract The gut microbiome has emerged as an important factor affecting human health and disease. The recent development of -omics approaches, including phylogenetic...
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Bio Roundup: Biogen at CTAD, Sage's Stumble, Astellas's $3B Offer & More

Bio Roundup: Biogen at CTAD, Sage's Stumble, Astellas's $3B Offer & More

2 days ago   |   Xconomy

It's been a roller-coaster year for those hoping for new drugs to treat Alzheimer's disease, a leading cause of death with rising treatment costs and no clear answer yet as to...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

IAmScience Mannie Liscum

IAmScience Mannie Liscum

For Mannie Liscum, thinking is a privilege, and his job gives him the chance to be fascinated by human's capacity to conceptualize and learn new things. “It's my goal to use as... Read more ...

MiR-552 promotes ovarian cancer progression by regulating PTEN pathway

Abstract Background Increasing researches have demonstrated the critical functions of MicroRNAs in the progression of malignant tumors, including ovarian cancer. It was... Read more ...

Exploration of cryptic organic photosensitive compound as Zincphyrin IV in...

Abstract Zincphyrin IV is a potential organic photosensitizer which is of significant interest for applications in biomedicine, materials science, agriculture , and chemistry... Read more ...

Three transcriptional regulators positively regulate the biosynthesis of...

Abstract Polycyclic tetramate macrolactams are a widely distributed class of structurally complex natural products, and most of them exhibit multiple biological activities... Read more ...

Faint gray bands in Drosophila melanogaster polytene chromosomes are formed...

Abstract In Drosophila melanogaster , the chromatin of interphase polytene chromosomes appears as alternating decondensed interbands and dense black or thin gray bands... Read more ...

A New Risk-Based Fuzzy Cognitive Model and Its Application to Decision-Making

Abstract Cognitive information in real-world decision-making problems is usually associated with all sorts of ambiguities and uncertainties. Fuzzy sets have been proposed as a... Read more ...

Analyzing the action of evolutionarily conserved modules on HMW-GS 1Ax1...

Abstract Key message The specific and high-level expression of 1Ax1 is determined by different promoter regions. HMW-GS synthesis occurs in aleurone layer cells. Heterologous... Read more ...

Achromobacter sp. FB-14 harboring ACC deaminase activity augmented rice...

Abstract Soil salinity is one of the major plant growth and yield-limiting constraints in arid and semi-arid regions of the world. In addition to the oxidative damage... Read more ...

Construction and Characterization of UBC4 Mutants with Single Residues...

Abstract Ubiquitination is tightly regulated to control degradation, localization and function of various proteins. Ubiquitination is catalysed by three enzymes, namely E1, E2... Read more ...

SPG8 mutations in Italian families: clinical data and literature review

Abstract Background Spastic paraplegia type 8 is an autosomal-dominant form of hereditary spastic paraplegia caused by a mutation in the KIAA0196 gene. SPG8 accounts for 1% of... Read more ...