Nature

Inscripta pushes funding to $260 million as they launch genome editing platform

10 hours ago   |   San Diego Biotechnology

Inscripta presentations can begin with the advent of agriculture. Or even further back: The emergence of man. Nandini Krishnamurthy “We've come a long way, starting with...
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Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression

12 hours ago   |   Springer

Abstract Background Gliomas are common life-threatening cancers, mainly due to their aggressive nature and frequent invasiveness and long non-coding RNAs are emerging as...
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Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome

22 hours ago   |   Springer

Abstract In this study, we perform a systematic analysis of evolutionary forces (i.e., mutational bias and natural selection) that shape the codon usage bias of human genes...
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Wing genes responsible for tiny treehopper's extraordinary helmet

1 day ago   |   ScienceDaily

Why the treehopper developed the enlarged, three-dimensional hood ornament that distinguishes it from the rest of the insect world remains a mystery to scientists, though it's...
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Three transcriptional regulators positively regulate the biosynthesis of polycyclic tetramate macrolactams in Streptomyces xiamenensis 318

1 day ago   |   Springer

Abstract Polycyclic tetramate macrolactams are a widely distributed class of structurally complex natural products, and most of them exhibit multiple biological activities...
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Understanding sheath blight resistance in rice: the road behind and the road ahead

2 days ago   |   Wiley

Abstract Rice Sheath blight disease, caused by the basidiomycetous necrotrophy Rhizoctonia solani, became one of the major threats to the rice cultivation worldwide, especially...
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Computational design of G Protein-Coupled Receptor allosteric signal transductions

3 days ago   |   ACS Division of Biological Chemistry   |   4 articles

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0407-2 A computational approach for designing GPCRs with new signaling functions including...
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Guided nuclear exploration increases CTCF target search efficiency

3 days ago   |   ACS Division of Biological Chemistry   |   4 articles

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0422-3 Single-particle tracking and mathematical modeling methods reveal the searching...
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Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development

3 days ago   |   ACS Division of Biological Chemistry   |   4 articles

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0415-2 The cellular stability of an oncogenic factor, AIMP2-DX2, is increased via...
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Resilient living materials built by printing bacterial spores

3 days ago   |   ACS Division of Biological Chemistry   |   4 articles

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0412-5 3D printing agarose hydrogels embedded with Bacillus subtilis spores produce...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Perceptive Unveils New $200M Fund to Invest in Early-Stage Biotechs

Perceptive Unveils New $200M Fund to Invest in Early-Stage Biotechs

Perceptive Advisors, an investment firm with a long track record of life science investing across all points of development, is now stepping up to pump money into companies at... Read more ...

Merck Makes a Big Blood Cancer Bet With $2.7B Deal for ArQule

Merck Makes a Big Blood Cancer Bet With $2.7B Deal for ArQule

Merck is acquiring cancer drug developer ArQule for $2.7 billion , a cash deal that brings it a promising early-stage compound that could challenge a blockbuster leukemia drug... Read more ...

KalVista Pharma Eye Drug Partnered With Merck Flunks Phase 2 Test

KalVista Pharma Eye Drug Partnered With Merck Flunks Phase 2 Test

A KalVista Pharmaceuticals eye drug at the center of a research collaboration with Merck has failed a mid-stage clinical trial. KalVista developed its drug, KVD001, to treat... Read more ...

Zentalis Steps Out With $147M Raised to Develop “Tried and True” Small Molecules

Zentalis Steps Out With $147M Raised to Develop “Tried and True” Small Molecules

Zentalis Pharmaceuticals is banking on small molecules for cancer-leaving the “cool technologies” aside for a “tried and true” approach, says the CEO, who wants to let the... Read more ...

Scripps Research, AbbVie Expand Drug Discovery Deal Beyond Cancer

Scripps Research, AbbVie Expand Drug Discovery Deal Beyond Cancer

The Scripps Research Institute and AbbVie have agreed to broaden an existing drug discovery agreement focused on cancer cell therapies to now encompass treatments for other... Read more ...

Eying Cancer Combos, Sanofi to Splash Out $2.5B on San Diego's Synthorx

Eying Cancer Combos, Sanofi to Splash Out $2.5B on San Diego's Synthorx

Synthorx is working to design new cytokine therapies for cancer using an “extended” genetic alphabet that could help avoid the shortcomings associated with earlier versions... Read more ...

Artificial Pancreas Keeps Patients Healthier: A Perspective

Artificial Pancreas Keeps Patients Healthier: A Perspective

The late Mayo endocrinologists Russell Wilder, M.D., and Randall Sprague, M.D., would be smiling today at the news for patients with diabetes. Much of their lives and careers... Read more ...

Aurinia Plans FDA Filing After Lupus Nephritis Drug Hits Phase 3 Goals

Aurinia Plans FDA Filing After Lupus Nephritis Drug Hits Phase 3 Goals

Aurinia shares spiked last week after voclosporin, an immunosuppressant being tested in patients with lupus nephritis, met its primary and secondary endpoints in a Phase 3... Read more ...

AstraZeneca Taps Gatehouse Bio to Identify Potential Drug Targets

AstraZeneca Taps Gatehouse Bio to Identify Potential Drug Targets

After joining AstraZeneca's Boston Bio Hub incubator last year, Gatehouse Bio is now teaming up with the pharma company to identify potential drug targets in respiratory and... Read more ...

Business Development Manager, Europe - Invetech - San Diego, CA

Selling a combination of consulting services and technical product solutions in biotech, cell and gene therapy markets. Global VP Commercial .From Fortive - Tue, 10 Dec 2019... Read more ...