Pathogenic variant

An overview of immunoinformatics approaches and databases linking T cell receptor repertoires to their antigen specificity

21 hours ago   |   Springer

Abstract Recent advances in molecular and bioinformatic methods have greatly improved our ability to study the formation of an adaptive immune response towards foreign...
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Auxotrophic mutations of Trichophyton rubrum created by in vitro synthesized Cas9 ribonucleoprotein

1 day ago   |   BMC Biotechnology

Trichophyton rubrum is an obligate human parasitic fungus and responsible for approximately 80-90% of dermatomycosis in human. Molecular genetic manipulations of this pathogen...
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Histone H2A isoforms: Potential implications in epigenome plasticity and diseases in eukaryotes

1 day ago   |   Journal of Biosciences

Abstract Epigenetic mechanisms including the post-translational modifications of histones, incorporation of histone variants and DNA methylation have been suggested to play an...
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Interfacial molecular interactions of cellobiohydrolase Cel7A and its variants on cellulose

2 days ago   |   Biotechnology for Biofuels

Molecular-scale mechanisms of the enzymatic breakdown of cellulosic biomass into fermentable sugars are still poorly understood, with a need for independent measurements of...
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Cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel

3 days ago   |   Genome Biology   |   2 articles

Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel that...
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A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis

4 days ago   |   ACS Division of Biological Chemistry   |   8 articles

Nature Chemical Biology, Published online: 13 January 2020; doi:10.1038/s41589-019-0437-9 In the fungal pathogen Cryptococcus neoformans, Bim1 is a copper-binding lytic...
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Plasmonic Biosensor Controlled by DNAzyme for On‐site Genetic Detection of Pathogens

5 days ago   |   Wiley

On‐site pre‐detection of pathogens could significantly decrease of a disease outbreak or national loss in most of the countries. However, conventional detection techniques were...
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Nanopore sequencing of African swine fever virus

5 days ago   |   Phys

African swine fever is one of the most pathogenic viral diseases in pigs caused by African swine fever virus. The fatality rate is almost 100%, which brings huge economic...
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PRAP: Pan Resistome analysis pipeline

6 days ago   |   BMC Bioinformatics

Antibiotic resistance genes can spread among pathogens via horizontal gene transfer, resulting in imparities in their distribution even within the same species. Therefore, a...
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The Open Targets Post-GWAS analysis pipeline

7 days ago   |   Oxford Journals

AbstractMotivationGenome-wide association studies are a powerful method to detect even weak associations between variants and phenotypes, however many of the identified...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Of Science and Sea Urchins: Researchers Plumb Oceans for Biological Insights

Of Science and Sea Urchins: Researchers Plumb Oceans for Biological Insights

The ocean is home to more biodiversity than anywhere else on the planet-making it a largely untapped source of opportunity for researchers studying marine organisms as a source... Read more ...

Holistic process development to mitigate proteolysis of a subunit rotavirus...

Abstract To meet the challenges of global health, vaccine design and development must be reconsidered to achieve cost of goods as low as 15¢ per dose. A new recombinant... Read more ...

Core-shell nanoparticles suppress metastasis and modify the...

Although accumulating evidence suggests that the crosstalk between malignant cells and cancer-associated fibroblasts actively contributes to tumour growth and metastatic... Read more ...

Ternary nanocomposite carriers based on organic clay-lipid vesicles as an...

This study aimed to develop a new colon-targeted drug delivery system via the preparation of ternary nanocomposite carriers based on organic polymer, aminoclay and lipid... Read more ...

New image analysis method for time-lapse microscopy shows how giant viruses...

Viruses are probably the most peculiar "life forms" known to us, with each species having unique characteristics. One thing common to all viruses is that they attack a "host... Read more ...

Advancing the application of genomic sequences through 'Kmasker plants'

The development of next-generation-sequencing has enabled researchers to investigate genomes that might previously have been considered too complex or too expensive... Read more ...

Benchmarking principal component analysis for large-scale single-cell...

Principal component analysis is an essential method for analyzing single-cell RNA-seq datasets, but for large-scale scRNA-seq datasets, computation time is long and consumes... Read more ...

Internet Freedom Ten Years In

Hillary Clinton gave her first speech on internet freedom 10 years ago today... Read more ...

Sismonr: Simulation of In Silico Multi-Omic Networks with adjustable ploidy...

AbstractSummaryWe present sismonr, an R package for an integral generation and simulation of in silico biological systems. The package generates gene regulatory networks, which... Read more ...

METADOCK 2: A high-throughput parallel metaheuristic scheme for molecular...

AbstractMotivationMolecular docking methods are extensively used to predict the interaction between protein-ligand systems in terms of structure and binding affinity, through... Read more ...