Protein

Structure‐sequence features based prediction of phosphosites of Serine/Threonine Protein Kinases of M. tuberculosis

4 days ago   |   Wiley   |   3 articles

Abstract Elucidation of signalling events in a pathogen is potentially important to tackle the infection caused by it. Such events mediated by protein phosphorylation play...
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Protein tertiary structure prediction and refinement using deep learning and Rosetta in CASP14

4 days ago   |   Wiley   |   3 articles

Abstract The trRosetta structure prediction method employs deep learning to generate predicted residue-residue distance and orientation distributions from which 3D models are...
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Protein structure prediction using deep learning distance and hydrogen‐bonding restraints in CASP14

4 days ago   |   Wiley   |   3 articles

ABSTRACT In this article, we report 3D structure prediction results by two of our best server groups in CASP14. These two servers were built based on the D-I-TASSER and D-QUARK...
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Molecular dynamics simulations reveal the disruption mechanism of a 2,4‐thiazolidinedione derivative C30 against tau hexapeptide oligomer

4 days ago   |   Wiley

Abstract 2,4-thiazolidinedione derivatives have been reported to inhibit the aggregation of tau protein, in which compound 30 can not only inhibit 80% of PHF6 aggregation, but...
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Labour‐saving construction of a target protein interaction network by selective culture and high‐throughput sequencing

4 days ago   |   Wiley

Abstract Background : Yeast two-hybrid is a classic method of screening for protein-protein interactions. However, the operation process is labour intensive and time consuming...
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Scientist Protein Chemistry - Encodia, Inc. - San Diego, CA

4 days ago   |   San Diego Biotechnology   |   10 articles

The qualified candidate will lead in-house high-throughput recombinant protein screening pipeline and develop scalable protein purification and characterization...From Encodia...
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Associate Scientist - Protein Engineering - Encodia, Inc. - San Diego, CA

5 days ago   |   San Diego Biotechnology   |   10 articles

We are seeking to recruit a skilled biochemist or molecular biologist with experience developing methodology to characterize novel protein interactions.From Encodia, Inc...
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Assessment of Protein Model Structure Accuracy Estimation in CASP14: Old and New Challenges

5 days ago   |   Wiley

Abstract In CASP, blind testing of model accuracy estimation methods has been conducted on models submitted by tertiary structure prediction servers. In CASP14, model accuracy...
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Protein oligomer modeling guided by predicted inter‐chain contacts in CASP14

5 days ago   |   Wiley   |   2 articles

Abstract For CASP14, we developed deep learning-based methods for predicting homo-oligomeric and hetero-oligomeric contacts and used them for oligomer modeling. To build...
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CRISPR‐Cereal: A Guide RNA Design Tool Integrating Regulome and Genomic Variation for Wheat, Maize and Rice

5 days ago   |   Wiley

Abstract The clustered regularly interspaced short palindromic repeat -associated protein genome editing system is revolutionizing agriculture. In this system, a guide sequence...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

MicroRNA-17-5p Promotes Cardiac Hypertrophy by Targeting Mfn2 to Inhibit...

Abstract Pathological cardiac hypertrophy is the leading cause of heart failure, and miRNAs have been recognized as key factors in cardiac hypertrophy. This study aimed to... Read more ...

Scientist, Hematologic and Immunologic Toxicology - La Jolla, CA - Johnson &...

As part of the cutting-edge Global Predictive, Investigative and Translational Toxicology Team, the candidate will have the opportunity to work within...From Johnson & Johnson... Read more ...

Bringing Protection Back in Line

Bringing Protection Back in Line

Research refines platform to address immune disorders Dr. Esma Yolcu and Dr. Haval Shirwan, Co-pioneers of ProtEx technology By Davis Suppes | Bond LSC The things that protect... Read more ...

After 40 Years, HIV Presents Research Problems New and Old

After 40 Years, HIV Presents Research Problems New and Old

In the years since AIDS was first described in medical research, the scientific map of that disease has changed enormously. Once it was relatively empty. Now scientists... Read more ...

Exosomal circRNA HIPK3 knockdown inhibited cell proliferation and metastasis...

Abstract Prostate cancer is the second frequent malignancy among men in the world. Exosomal circular RNAs have been reported to function in PCa progression. The current study... Read more ...

Prognostic value and immunological characteristics of a novel...

Abstract Autophagy affects the development, progression, and prognosis of various cancers including pancreatic cancer. To develop an autophagy-related prognostic model of... Read more ...

Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and...

Chirality is a fundamental characteristic of natural molecules and a crucial factor in the biochemical reactions of living cells and organisms. Recently, researchers have... Read more ...

Ramil the snow leopard tests positive for COVID at the San Diego Zoo

Zoo staff say the animal's symptoms are mild and are still investigating how he got infected Read more ...

Enhanced lignin biodegradation by consortium of white rot fungi: microbial...

As one of the major components of lignocellulosic biomass, lignin has been considered as the most abundant renewable aromatic feedstock in the world. Comparing with thermal or... Read more ...

Design and heterologous expression of a novel dimeric LL37 variant in Pichia...

The antimicrobial peptide LL37 is produced by white blood cells and various epithelial cells, and has the outstanding advantages of participating in immune regulation, causing... Read more ...