Research

Joint detection of germline and somatic copy number events in matched tumor-normal sample pairs

12 minutes ago   |   Oxford Journals

AbstractMotivationWhole-genome sequencing of tumor-normal sample pairs is a powerful approach for comprehensively characterizing germline copy number variations and somatic...
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Benchmarking of 4C-seq pipelines based on real and simulated data

12 minutes ago   |   Oxford Journals

AbstractMotivationWith its capacity for high-resolution data output in one region of interest, chromosome conformation capture combined with high-throughput sequencing is a...
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102978 Staff Research Associate

42 minutes ago   |   San Diego Biotechnology

MEDICINE Salary commensurate with qualifications and experienceFiling Deadline: Mon 12/16/2019...
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Editorial focus: understanding off-target effects as the key to successful RNAi therapy

1 hour ago   |   Springer   |   2 articles

Abstract With the first RNA interference drug ) on the market, we witness the RNAi therapy field reaching a critical turning point, when further improvements in drug candidate...
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Genomic cut and paste using a class 1 CRISPR system

1 hour ago   |   Phys

Almost from the moment DNA was discovered, the ability to fix or remove disease-causing genes in affected patients has been something of a holy grail of medicine. Now that this...
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FlowEMMi: an automated model-based clustering tool for microbial cytometric data

3 hours ago   |   Springer

Abstract Background Flow cytometry is a powerful single-cell based measurement method to ascertain multidimensional optical properties of millions of cells. FCM is widely used...
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ASH: Amgen's BiTE stalls multiple myeloma relapse in mice in combo with BMS' Revlimid

4 hours ago   |   Fierce Biotech

Amgen is developing two bispecific T-cell engagers for multiple myeloma, one of which is designed with a longer half-life that could lessen the infusion time required for...
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CRISPR System: A High-throughput Toolbox for Research and Treatment of Parkinson's Disease

9 hours ago   |   Springer

Abstract In recent years, the innovation of gene-editing tools such as the CRISPR/Cas9 system improves the translational gap of treatments mediated by gene therapy. The...
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MiR-552 promotes ovarian cancer progression by regulating PTEN pathway

10 hours ago   |   Springer   |   2 articles

Abstract Background Increasing researches have demonstrated the critical functions of MicroRNAs in the progression of malignant tumors, including ovarian cancer. It was...
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A New Risk-Based Fuzzy Cognitive Model and Its Application to Decision-Making

11 hours ago   |   Springer

Abstract Cognitive information in real-world decision-making problems is usually associated with all sorts of ambiguities and uncertainties. Fuzzy sets have been proposed as a...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

AstraZeneca Taps Gatehouse Bio to Identify Potential Drug Targets

AstraZeneca Taps Gatehouse Bio to Identify Potential Drug Targets

After joining AstraZeneca's Boston Bio Hub incubator last year, Gatehouse Bio is now teaming up with the pharma company to identify potential drug targets in respiratory and... Read more ...

IAmScience Mannie Liscum

IAmScience Mannie Liscum

For Mannie Liscum, thinking is a privilege, and his job gives him the chance to be fascinated by human's capacity to conceptualize and learn new things. “It's my goal to use as... Read more ...

ASH Poster 2019

Initial findings of the Phase 1 trial of PBCAR0191 Presenter: Bijal Shah, MD, Moffitt Cancer Center Session: 627. Aggressive Lymphoma (Diffuse Large... Read more ...

102978 Staff Research Associate

MEDICINE Salary commensurate with qualifications and experienceFiling Deadline: Mon 12/16/2019... Read more ...

Accurate prediction of protein beta-aggregation with generalized statistical...

AbstractMotivationProtein beta-aggregation is an important but poorly understood phenomena involved in diseases as well as in beneficial physiological processes. However, while... Read more ...

PgRC: Pseudogenome based Read Compressor

AbstractMotivationThe amount of sequencing data from High-Throughput Sequencing technologies grows at a pace exceeding the one predicted by Moore's law. One of the basic... Read more ...

PyDockEneRes: per-residue decomposition of protein-protein docking energy

AbstractMotivationProtein-protein interactions are key to understand biological processes at the molecular level. As a complement to experimental characterization of protein... Read more ...

CpGtools: A Python Package for DNA Methylation Analysis

AbstractMotivationDNA methylation can be measured at the single CpG level using sodium bisulfite conversion of genomic DNA followed by sequencing or array hybridization. Many... Read more ...

SpaCell: integrating tissue morphology and spatial gene expression to...

AbstractMotivationSpatial transcriptomics technology is increasingly being applied because it enables the measurement of spatial gene expression in an intact tissue along with... Read more ...

CRISPR-resistant viruses build 'safe rooms' to shield genomes from...

Bacteria and the viruses that infect them are engaged in a molecular arms race as ancient as life itself. Evolution has equipped bacteria with an arsenal of immune enzymes... Read more ...