Genes

Mesenchymal stem cells engineered by modified polyethylenimine polymer for targeted cancer gene therapy, in vitro and in vivo

9 days ago   |   By Wiley

Abstract
Cell‐based delivery system is a promising strategy to protect therapeutic agents from the immune system and provide targeted delivery. Mesenchymal stem cells have recently been introduced as an encouraging vehicle in cell‐based gene therapy due to their unique features including tumor‐tropic property and migratory ability. However, gene transfer into MSCs is limited due to low efficiency and cytotoxicity of carriers. In this study, we designed a novel delivery system based on polyethylenimine to improve these features of carrier and transfect plasmid encoding TRAIL to MSCs. Tumor...
Read more ...

 

ThETA: Transcriptome-driven Efficacy estimates for gene-based TArget discovery

9 days ago   |   By Oxford Journals

AbstractSummaryEstimating efficacy of gene target-disease associations is a fundamental step in drug discovery. An important data source for this laborious task is RNA expression, which can provide gene-disease associations on the basis of expression fold change and statistical significance. However, the simply use of the log fold change can lead to numerous false positive associations. On the other hand, more sophisticated methods that utilize gene co-expression networks do not consider tissue specificity. Here we introduce ThETA (Transcriptome-driven Efficacy estimates for gene-based...
Read more ...

 


Search by Tags

   Genes      Immunity      Therapeutics      Therapies      Cancer      Gene Therapy      Engineering      Gene      Discovery      Tissue      Drug      RNA      Drugs  


World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Forma Therapeutics Eyes IPO to Advance Sickle Cell, Prostate Cancer Drugs

Forma Therapeutics Eyes IPO to Advance Sickle Cell, Prostate Cancer Drugs

Forma Therapeutics has developed a pipeline of small molecules aimed at rare blood disorders and cancers, but it aims to advance two-investigational treatments for sickle cell... Read more ...

Bio Roundup: ASCO Opens, Merck Takes On COVID, Evofem's Approval & More

Bio Roundup: ASCO Opens, Merck Takes On COVID, Evofem's Approval & More

A year ago about 40,000 people gathered in Chicago for the annual meeting of the American Society of Clinical Oncology. Today a virtual version of the ASCO conference, the... Read more ...

AbbVie Wins First FDA Approval of Drug to Treat Uterine Fibroid Bleeds

AbbVie Wins First FDA Approval of Drug to Treat Uterine Fibroid Bleeds

An AbbVie drug that treats pain in the uterus has notched an additional FDA approval for addressing heavy menstrual bleeding associated with uterine fibroids. The regulatory... Read more ...

Daya Bay Reactor Experiment Continues to Generate Data

Daya Bay Reactor Experiment Continues to Generate Data

Antineutrino detectors are submersed in liquid at the Daya Bay experiment, as seen during the final phase of construction in August 2012. Experiment: Daya Bay reactor neutrino... Read more ...

Seeing Cancer, But Not Through a Microscope

Seeing Cancer, But Not Through a Microscope

Toward the end of the 19th century, a French doctor named Ernest Besnier coined the term “ biopsy ,” combining the Greek bios and opsis. In the decades since, clinicians have... Read more ...

Variant Emerges With $16M to Find “Outlier Humans” to Reveal New Drugs

Variant Emerges With $16M to Find “Outlier Humans” to Reveal New Drugs

Human DNA holds secrets that, once uncovered, have led scientists to develop a number of treatments for disease. A slew of biopharmas and biotechs-not to mention national... Read more ...

Don't Wait for “Them” to Find Your Weaknesses

Don't Wait for “Them” to Find Your Weaknesses

Our Professional Services Written by: Crystal Booth, M.M.- Regional Manager, Southeast USA at PSC Biotech We've probably all heard the phrase “audit ready state”. But what does... Read more ...

RTRIP: a comprehensive profile of transposon insertion polymorphisms in rice

Abstract Transposable elements , also known as transposons, a type of mobile genetic elements, are widespread across all investigated eukaryotic organisms and typically... Read more ...

Functional oral nanoparticles for delivering silibinin and cryptotanshinone...

Breast cancer lung metastasis occurs in more than 60% of all patients with breast cancer, and most of those afflicted by it eventually die of recurrence. The tumor... Read more ...

Escherichia coli metabolism under short-term repetitive substrate dynamics...

Microbial metabolism is highly dependent on the environmental conditions. Especially, the substrate concentration, as well as oxygen availability, determine the metabolic... Read more ...