Biology

Molecular Dynamics Simulations to the Bidirectional Adhesion Signaling Pathway of Integrin αVβ3

13 days ago   |   By Wiley

Abstract
The bidirectional force transmission process of integrin through the cell membrane is still not well understood. Several possible mechanisms have been discussed in literature on the basis of experimental data, and in this study, we investigate these mechanisms by free and steered molecular dynamics simulations. For the first time constant velocity pulling on the complete integrin molecule inside a DPPC membrane is conducted. From the results the most likely mechanism for inside‐out and outside‐in signaling is the switchblade model with further separation of the transmembrane...
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Measuring cell-cell forces using snapshots from time-lapse videos of cells

14 days ago   |   By ScienceDaily

A new computational method can measure the forces cells exert on each other by analyzing time-lapse videos of cell colonies. It could enable researchers to gain fundamental insights into what role intercellular forces play in cellular biology and how they differ in healthy and diseased states.
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World Biotechnology Congress 2019

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