Genome

ATAV: a comprehensive platform for population-scale genomic analyses

2 monthes ago   |   By BMC Bioinformatics

A common approach for sequencing studies is to do joint-calling and store variants of all samples in a single file. If new samples are continually added or controls are re-used for several studies, the cost an...
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Efficient deletion of multiple circle RNA loci by CRISPR‐Cas9 reveals Os06circ02797 as a putative sponge for OsMIR408 in rice

2 monthes ago   |   By Wiley

Summary
CRISPR‐Cas9 is an emerging genome editing tool for reverse genetics in plants. However, its application for functional study of non‐coding RNAs in plants is still at its infancy. Despite being a major class of non‐coding RNAs, the biological roles of circle RNAs remain largely unknown in plants. Previous plant circRNA studies have focused on identification and annotation of putative circRNAs, with their functions largely uninvestigated by genetic approaches. Here, we applied a multiplexed CRISPR‐Cas9 strategy to efficiently acquire individual null mutants for four circRNAs in rice...
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CRISPR/Cas9‐mediated genome editing of MaACO1 (aminocyclopropane‐1‐carboxylate oxidase 1) promotes the shelf life of banana fruit

2 monthes ago   |   By Wiley

Plant Biotechnology Journal, EarlyView.
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Simultaneous knock‐out of multiple LHCF genes using single sgRNAs and engineering of a high fidelity Cas9 for precise genome editing in marine algae

2 monthes ago   |   By Wiley

Abstract
The CRISPR/Cas9 system is an RNA‐guided sequence specific genome editing tool, which has been adopted for single or multiple gene editing in a wide range of organisms. When working with gene families with functional redundancy, knocking out multiple genes within the same family may be required to generate a phenotype. In this study, we tested the possibility of exploiting the known tolerance of Cas9 for mismatches between the single guide RNA and target site to simultaneously introduce indels in multiple homologous genes in the marine diatom Phaeodactylum tricornutum. As a proof...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Warehouse Associate - Inovio Pharmaceuticals - San Diego, CA

The temporary Warehouse Associate is responsible for safely performing the assigned warehouse functions, such as monitoring and reconciling inventory levels,...From Indeed... Read more ...

Zeroing in on APOE gene to better understand aging, Alzheimer's disease

Zeroing in on APOE gene to better understand aging, Alzheimer's disease

The apolipoprotein E, or APOE , gene is the strongest genetic risk factor for Alzheimer's disease , as most people who get the disease carry the gene. The gene has far-reaching... Read more ...

Modular biosynthesis of plant hemicellulose and its impact on yeast cells

The carbohydrate polymers that encapsulate plants cells have benefited humans for centuries and have valuable biotechnological uses. In the past 5 years, exciting possibilities... Read more ...

Genetic tools for the development of recombinant lactic acid bacteria

Lactic acid bacteria are a phylogenetically diverse group with the ability to convert soluble carbohydrates into lactic acid. Many LAB have a long history of safe use in... Read more ...

How cells 'read' artificial ingredients tossed into genetic recipe

Researchers discovered that the enzyme RNA polymerase II recognizes and transcribes artificially added base pairs in genetic code, a new insight that could help advance the... Read more ...

Start-stop system of hunting immune cells

Researchers decipher the basic biology of neutrophil swarming and now show that the cells also evolved an intrinsic molecular program to self-limit their swarming activity. The... Read more ...

Research Associate - Synthetic Genomics - La Jolla, CA

The successful candidate will support the characterization of metagenomic communities, isolation and characterization of individual strains, and development of...From Synthetic... Read more ...

Author Correction: Highly recurrent CBS epimutations in gastric cancer CpG...

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LIQA: long-read isoform quantification and analysis

Long-read RNA sequencing technologies can sequence full-length transcripts, facilitating the exploration of isoform-specific gene expression over short-read RNA-seq. We present... Read more ...

Hired blade: Anchoring complex in plant cells recruits its own katana sword

Researchers have found that an anchoring complex in plant cells recruits its own version of the katana sword for cutting microtubules. The Msd1-Wdr8 complex is used to... Read more ...