Protein

Performance and enhancement of the LZerD protein assembly pipeline in CAPRI 38‐46

11 days ago   |   By Wiley

Abstract
We report the performance of the protein docking prediction pipeline of our group and the results for CAPRI rounds 38‐46. The pipeline integrates programs developed in our group as well as other existing scoring functions. The core of the pipeline is the LZerD protein‐protein docking algorithm. If templates of the target complex are not found in PDB, the first step of our docking prediction pipeline is to run LZerD for a query protein pair. Meanwhile, in the case of human group prediction, we survey the literature to find information that can guide the modeling, such as...
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Enhanced sampling of protein conformational states for dynamic cross‐docking within the protein‐protein docking server SwarmDock

11 days ago   |   By Wiley

ABSTRACT
The formation of specific protein‐protein interactions is often key to a protein's function. During complex formation, each protein component will undergo a change of conformational state, for some these changes are relatively small and reside primarily at the sidechain level; however, others may display notable backbone adjustments. One of the classic problems in the protein docking field is to be able to a priori predict the extent of such conformational changes. In this work, we investigated three protocols to find the most suitable input structure conformations for...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Cover Image, Volume 87, Issue 12

Cover Image, Volume 87, Issue 12

Obverse Cover: The cover image has been created for this special issue by Maya Topf, Sony Malhotra, and Andriy Kryshtafovych. The highlight of CASP13 experiment is the... Read more ...

Patient Storytelling: There's an Art to it!

Patient Storytelling: There's an Art to it!

After 30-plus years working in Washington DC, it's clear healthcare decision makers recognize that a patient's story can add value to a discussion when data cannot. While the... Read more ...

: Associate Director, Biology

: Summary: Alaya Bioscience is a startup biotech company developing novel nanotherapeutics for infectious diseases. We are seeking an Associate Dire... 92121, San Diego ... Read more ...

Tracking inheritance of human mitochondrial DNA

New insight into how genetic information stored in human mitochondria is passed from one generation to the next could have important implications for genetic counseling of... Read more ...

Researchers clear the path for 'designer' plants

A team of researchers at the University of Georgia has found a way to identify gene regulatory elements that could help produce "designer" plants and lead to improvements in... Read more ...

New method takes analysis of genetic libraries to next level

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Fate Therapeutics: Manager, Quality Assurance

Fate Therapeutics: Fate Therapeutics seeks an experienced, motivated Manager of Quality Assurance to support Fate's internal and external cGMP manufacturing operations. 92121... Read more ...

Discovery of disease- and drug-specific pathways through community...

AbstractMotivationIn light of the massive growth of the scientific literature, text mining is increasingly used to extract biological pathways. Though multiple tools explore... Read more ...

SPDI: Data Model for Variants and Applications at NCBI

AbstractMotivationNormalizing sequence variants on a reference, projecting them across congruent sequences, and aggregating their diverse representations are critical to the... Read more ...

DeepMSA: constructing deep multiple sequence alignment to improve contact...

AbstractMotivationThe success of genome sequencing techniques has resulted in rapid explosion of protein sequences. Collections of multiple homologous sequences can provide... Read more ...