Research

DiNGO: standalone application for Gene Ontology and Human Phenotype Ontology term enrichment analysis

11 days ago   |   By Oxford Journals

AbstractSummaryAlthough various tools for Gene Ontology term enrichment analysis are available, there is still room for improvement. Hence, we present DiNGO, a standalone application based on an open source code from BiNGO, a widely-used application to assess the overrepresentation of GO categories. Besides facilitating GO term enrichment analyses, DiNGO has been developed to allow for convenient Human Phenotype Ontology term overrepresentation investigation. This is an important contribution considering the increasing interest in HPO in scientific research and its potential in clinical...
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BAGSE: A Bayesian Hierarchical Model Approach for Gene Set Enrichment Analysis

11 days ago   |   By Oxford Journals

AbstractMotivationGene set enrichment analysis has been shown to be effective in identifying relevant biological pathways underlying complex diseases. Existing approaches lack the ability to quantify the enrichment levels accurately, hence preventing the enrichment information to be further utilized in both upstream and downstream analyses. A modernized and rigorous approach for gene set enrichment analysis that emphasizes both hypothesis testing and enrichment estimation is much needed.ResultsWe propose a novel computational method, Bayesian Analysis of Gene Set Enrichment , for gene set...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Cover Image, Volume 87, Issue 12

Cover Image, Volume 87, Issue 12

Reverse Cover: The cover image is based on the Review Critical assessment of methods of protein structure prediction ‐Round XIII by Andriy Kryshtafovych, Torsten Schwede, Maya... Read more ...

With “Inflection Year” Ahead, Ovid Adds Novartis's Tardio to C-Suite

With “Inflection Year” Ahead, Ovid Adds Novartis's Tardio to C-Suite

About five years ago, former Teva Pharmaceutical CEO Jeremy Levin launched Ovid Therapeutics with a plan to develop treatments for rare brain diseases. Now, with the completion... Read more ...

Underdog Launches With $4M to Target “Toxic” Form of Cholesterol

Underdog Launches With $4M to Target “Toxic” Form of Cholesterol

Underdog Pharmaceuticals has launched with nearly $4 million in seed funding to develop treatments for atherosclerosis, a progressive condition in which arteries become clogged... Read more ...

Alkermes Eyes Brain Disorders and Beyond With $100M Deal for Rodin

Alkermes Eyes Brain Disorders and Beyond With $100M Deal for Rodin

Rodin Therapeutics has limited data from human studies about its neurodegeneration drug, but the company's new approach to treating brain disorders has proven attractive enough... Read more ...

Yelick Recognized for Outstanding Leadership in HPC

Yelick Recognized for Outstanding Leadership in HPC

Katherine Yelick has been honored by HPCwire as their Editor's Choice for Outstanding Leadership in high-performance computing. (Photo courtesy of Berkeley Lab Computing... Read more ...

Patient Storytelling: There's an Art to it!

Patient Storytelling: There's an Art to it!

After 30-plus years working in Washington DC, it's clear healthcare decision makers recognize that a patient's story can add value to a discussion when data cannot. While the... Read more ...

BRM: A statistical method for QTL mapping based on bulked segregant analysis...

AbstractMotivationBulked segregant analysis by deep sequencing has been widely used for QTL mapping in recent years. A number of different statistical methods for BSA-seq have... Read more ...

HypercubeME: two hundred million combinatorially complete datasets from a...

AbstractMotivationEpistasis, the context-dependence of the contribution of an amino acid substitution to fitness, is common in evolution. To detect epistasis, fitness must be... Read more ...

An Integrative Approach for Fine-Mapping Chromatin Interactions

AbstractMotivationChromatin interactions play an important role in genome architecture and regulation. The Hi-C assay generates such interactions maps genome-wide, but at... Read more ...

KofamKOALA: KEGG ortholog assignment based on profile HMM and adaptive score...

AbstractSummaryKofamKOALA is a web server to assign KEGG Orthologs to protein sequences by homology search against a database of profile hidden Markov models with pre-computed... Read more ...