Therapeutics

Design and characterization of novel dual Fc antibody with enhanced avidity for Fc receptors

10 days ago   |   By Wiley

Abstract
Monoclonal antibodies have become an important class of therapeutics, particularly in the realm of anti‐cancer immunotherapy. While the two antigen‐binding fragments of a mAb allow for high‐avidity binding to molecular targets, the crystallizable fragment engages immune effector elements. mAbs of the IgG class are used for the treatment of autoimmune diseases and can elicit anti‐tumor immune functions by several mechanisms including direct antigen engagement via their Fab arms, but also by Fab binding to tumors combined with Fc engagement of complement component C1q and Fc γ...
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