Tissue

SpaCell: integrating tissue morphology and spatial gene expression to predict disease cells

1 month ago   |   By Oxford Journals

AbstractMotivationSpatial transcriptomics technology is increasingly being applied because it enables the measurement of spatial gene expression in an intact tissue along with imaging morphology of the same tissue. However, current analysis methods for spatial transcriptomics data do not use image pixel information, thus missing the quantitative links between gene expression and tissue morphology.ResultsWe developed a user-friendly deep learning software, SpaCell, to integrate millions of pixel intensity values with thousands of gene expression measurements from spatially-barcoded spots in...
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