Animals

A Game-Changing Test for Prion, Alzheimer's, and Parkinson's Diseases is on the Horizon

12 days ago   |   By News Center

Ronald Zuckermann and Michael Connolly hold a model of a protein in a beta sheet arrangement. Aggregates of proteins misfolded into this shape are the disease-causing agents in numerous fatal neurodegenerative diseases. The team's peptoid-coated magnetic beads can bind to these aggregates, allowing scientists to detect them in samples of body fluids.
There are currently no effective treatments for prion diseases, a family of fatal neurodegenerative conditions caused by accumulations of misfolded copies of a naturally occurring protein. But now, there is finally an effective way to test...
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Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1

Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1

12 days ago   |   By Springer

Abstract
DJ-1 is a protein with a wide range of functions importantly related to redox regulation in the cell. In humans, dysfunction of the PARK7 gene is associated with neurodegeneration and Parkinson's disease. Our objective was to establish a novel DJ-1 knockout zebrafish line and to identify early brain proteome changes, which could be linked to later pathology. The CRISPR-Cas9 method was used to target exon 1 of the park7-/- gene to produce a transgenic DJ-1-deficient zebrafish model of Parkinson's disease. Label-free mass spectrometry was employed to identify altered protein...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Cover Image, Volume 87, Issue 12

Cover Image, Volume 87, Issue 12

Reverse Cover: The cover image is based on the Review Critical assessment of methods of protein structure prediction ‐Round XIII by Andriy Kryshtafovych, Torsten Schwede, Maya... Read more ...

Patient Storytelling: There's an Art to it!

Patient Storytelling: There's an Art to it!

After 30-plus years working in Washington DC, it's clear healthcare decision makers recognize that a patient's story can add value to a discussion when data cannot. While the... Read more ...

Discovery of disease- and drug-specific pathways through community...

AbstractMotivationIn light of the massive growth of the scientific literature, text mining is increasingly used to extract biological pathways. Though multiple tools explore... Read more ...

SPDI: Data Model for Variants and Applications at NCBI

AbstractMotivationNormalizing sequence variants on a reference, projecting them across congruent sequences, and aggregating their diverse representations are critical to the... Read more ...

DeepMSA: constructing deep multiple sequence alignment to improve contact...

AbstractMotivationThe success of genome sequencing techniques has resulted in rapid explosion of protein sequences. Collections of multiple homologous sequences can provide... Read more ...

SBML2Modelica: Integrating biochemical models within open-standard...

AbstractMotivationSBML is the most widespread language for the definition of biochemical models. Although dozens of SBML simulators are available, there is a general lack of... Read more ...

Link-HD: a versatile framework to explore and integrate heterogeneous...

AbstractMotivationWe present Link-HD, an approach to integrate multiple datasets. Link-HD is a generalization of STATIS-ACT (‘Structuration des Tableaux A Trois Indices de la... Read more ...

Struggling Alkermes spends $950M sculpting Rodin buyout

Just a month ago, Alkermes was announcing it was slashing scores of jobs; now, it's willing to put down nearly $1 billion to buy out CNS biotech Rodin Therapeutics. Read more ...

AHA: MedCo's PCSK9 rival inclisiran hits LDL

The Medicines Company has posted more late-phase data linking its siRNA inclisiran to steep declines in LDL cholesterol. Inclisiran achieved a placebo-adjusted drop in LDL... Read more ...

AHA: Caladrius single injection helps heart disease that hits women the hardest

We tend to think of heart disease and heart disorders to be, in the main, things that affect men more than women, but this is of course not true. Read more ...